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Histone H2A ubiquitination

Biomarker

1 paper2 findings

  • Animals1

Upstream

1

BRAP

downin mice1

1 study

  1. BRAP decreases histone H2A ubiquitination in mice.

    “abrogating Brap, a BRCA1-associated protein essential for neurogenesis, results in persistent DNA double-strand breaks and elevation of histone H2A mono- and poly-ubiquitination (H2Aub).”

    Animalsshown by Brap loss of function

    Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration

    iScienceJun 3, 2022

More on BRAP

Associations

1

Alzheimer's disease

upin humans1

1 study

  1. Alzheimer's disease is associated with histone H2A ubiquitination in humans.

    “We further show the elevation of H2Aub also occurs in human brain tissues with Alzheimer's disease.”

    HumansAlzheimer's diseasebrain

    Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration

    iScienceJun 3, 2022

More on Alzheimer's disease

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