ZC3HC1

1. ZC3HC1 has no effect on senescence-associated secretory phenotype (SASP) in human cells.

   “knockdown of ZC3HC1 does not compromise the formation of senescence-associated heterochromatin foci or activation of the senescence-associated secretory phenotype”

   Cellsduring oncogene-induced senescence in human fibroblastssiRNAfibroblasts

   ZC3HC1 has many functions distinct from TPR and is dispensable for TPR localisation to the nuclear basket

   Wellcome open research·May 30, 2025

More on Senescence-associated secretory phenotype (SASP)

1. ZC3HC1 has no effect on chromatin and 3D genome organization in human cells.

   “knockdown of ZC3HC1 does not compromise the formation of senescence-associated heterochromatin foci”

   Cellsduring oncogene-induced senescence in human fibroblastssiRNAfibroblasts

   ZC3HC1 has many functions distinct from TPR and is dispensable for TPR localisation to the nuclear basket

   Wellcome open research·May 30, 2025

More on Chromatin and 3D genome organization

1. ZC3HC1 has no effect on TPR localization to nuclear pores in human cells.

   “TPR remains localised to pores when ZC3HC1 is depleted”

   Cellsknockdown of ZC3HC1 in human fibroblastssiRNAfibroblasts

   ZC3HC1 has many functions distinct from TPR and is dispensable for TPR localisation to the nuclear basket

   Wellcome open research·May 30, 2025