asah2

1. asah2 increases senescent cell accumulation in killifish.

   “attenuates systemic ageing phenotypes, including declines in locomotor activity, abnormal protein accumulation in the brain, and accumulation of senescent cells in the liver.”

   Animalsshown by asah2 knockoutliver

   Inhibition of the gut ceramidase Asah2 decelerates the vertebrate ageing rate

   bioRxiv (Cold Spring Harbor Laboratory)·4 May 2026Preprint

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