ARF4

1. ARF4 is associated with immune regulation and microglial homeostasis transcriptomic signatures in mice.

   “Arf4 knockdown further led to transcriptomic alterations in the mouse brain; most pronounced in pathways associated with immune regulation and microglial homeostasis.”

   Animalsshown by Arf4 knockdown in PSAPP/Arf4 +/− micebrain

   The effects of Arf4 gene knockdown on Alzheimer's amyloid β deposition: Possible role in cognitive resilience

   Research Square·14 Oct 2026Preprint

More on Immune regulation and microglial homeostasis transcriptomic signatures

1. ARF4 is associated with APP localization in mice.

   “The consequence of Arf4 knockdown was an alteration in amyloid precursor protein (APP) localization, which led to variations in mature APP levels.”

   Animalsshown by Arf4 knockdown in PSAPP/Arf4 +/− mice

   The effects of Arf4 gene knockdown on Alzheimer's amyloid β deposition: Possible role in cognitive resilience

   Research Square·14 Oct 2026Preprint

More on APP localization

1. ARF4 is associated with cognitive resilience in humans.

   “identified ADP ribosylation factor 4 (ARF4) as one of the key driver genes associated with resilience among the oldest-old (OO) non-demented individuals.”

   Humansnon-demented individuals

   The effects of Arf4 gene knockdown on Alzheimer's amyloid β deposition: Possible role in cognitive resilience

   Research Square·14 Oct 2026Preprint