Immune regulation and microglial homeostasis transcriptomic signatures

1. ARF4 is associated with immune regulation and microglial homeostasis transcriptomic signatures in mice.

   “Arf4 knockdown further led to transcriptomic alterations in the mouse brain; most pronounced in pathways associated with immune regulation and microglial homeostasis.”

   Animalsshown by Arf4 knockdown in PSAPP/Arf4 +/− micebrain

   The effects of Arf4 gene knockdown on Alzheimer's amyloid β deposition: Possible role in cognitive resilience

   Research Square·14 Oct 2026Preprint

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