APPPS1

1. APPPS1 increases pyruvate kinase activity in mice.

   “APPPS1 mice possessed higher pyruvate kinase activity than WT mice in all organs and higher hexokinase and phosphofructokinase activities in the brain, with stronger effects in males.”

   Animalscompared to WT micebrain, liver, kidney

   Body-Wide Glycolytic Shift, Oxidative Stress, and Sex-Specific Effect of Caloric Restriction in a Mouse Model of Alzheimer's Disease

   Antioxidants (Basel, Switzerland)·2 Feb 2026

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1. APPPS1 increases oxidative stress markers in mice.

   “Compared to age-matched WT controls, the brain, liver, and kidney of 9-month-old AL APPPS1 mice exhibited higher levels of oxidative stress markers, higher superoxide dismutase, and lower catalase activities.”

   Animalsad libitum fed vs age-matched WT controlsbrain, liver, and kidney

   Body-Wide Glycolytic Shift, Oxidative Stress, and Sex-Specific Effect of Caloric Restriction in a Mouse Model of Alzheimer's Disease

   Antioxidants (Basel, Switzerland)·2 Feb 2026

More on Oxidative stress markers