AgingResearch.NewsJoin free

APOE4-R47H

There is 1 paper on APOE4-R47H in aging research: none in people yet, 1 in animals.

Gene

1 paper studies it1 finding

See all 1

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab
  • Animals1

Effects

1

Cellular senescence

upin mice1

1 study

  1. APOE4-R47H increases cellular senescence in microglia, cGAS- and BAX-dependent.

    “APOE4-R47H microglia displayed cGAS- and BAX-dependent upregulation of senescence”

    Animalsin microglia, cGAS- and BAX-dependentmicrogliafemales

    Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model

    bioRxiv : the preprint server for biologyPreprint

More on Cellular senescence

Latest

Related