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ALTRE

Gene

1 paper studies it4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funder: National Natural Science Foundation of China
  • Animals1

Effects

4

Apoptosis

downin mice1

1 study

  1. ALTRE inhibits apoptosis in mice.

    “Depletion of Altre reduced Treg mitochondrial integrity and respiratory capacity, and induced reactive oxygen species accumulation, thus increasing intrahepatic Treg apoptosis in aged mice.”

    Animalsdepletionliver

    A Treg-specific long noncoding RNA maintains immune-metabolic homeostasis in aging liver

    Nature agingJun 5, 2023

More on Apoptosis

Inflammation

downin mice1

1 study

  1. ALTRE inhibits inflammation in mice.

    “Treg-specific deletion of Altre did not affect Treg homeostasis and function in young mice but caused Treg metabolic dysfunction, inflammatory liver microenvironment, liver fibrosis and liver cancer in aged mice.”

    AnimalsTreg-specific deletionliver

    A Treg-specific long noncoding RNA maintains immune-metabolic homeostasis in aging liver

    Nature agingJun 5, 2023

More on Inflammation

Liver cancer

downin mice1

1 study

  1. ALTRE prevents liver cancer in mice.

    “Treg-specific deletion of Altre did not affect Treg homeostasis and function in young mice but caused Treg metabolic dysfunction, inflammatory liver microenvironment, liver fibrosis and liver cancer in aged mice.”

    AnimalsTreg-specific deletionliver

    A Treg-specific long noncoding RNA maintains immune-metabolic homeostasis in aging liver

    Nature agingJun 5, 2023

More on Liver cancer

Liver fibrosis

downin mice1

1 study

  1. ALTRE prevents liver fibrosis in mice.

    “Treg-specific deletion of Altre did not affect Treg homeostasis and function in young mice but caused Treg metabolic dysfunction, inflammatory liver microenvironment, liver fibrosis and liver cancer in aged mice.”

    AnimalsTreg-specific deletionliver

    A Treg-specific long noncoding RNA maintains immune-metabolic homeostasis in aging liver

    Nature agingJun 5, 2023

More on Liver fibrosis

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