Papillary muscle T1

1. Papillary muscle T1 decreases left ventricular ejection fraction in humans.

   “PM T1 was also independently associated with increased atrial and ventricular volumes and lower atrial and left ventricular ejection fraction”

   Humansadjusted for age, sex, body mass index, and LV T1papillary musclen = 51,316

   Machine Learning-Enabled Papillary Muscle Fibrosis Assessment in 51,000 Individuals Reveals Independent Links to Cardiac Structure, Function, and Disease and Identifies Genetic Susceptibility Loci

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

1. Papillary muscle T1 is associated with ventricular arrhythmias in humans (43% increase in odds per 100 ms).

   “PM T1 (/100 ms) was significantly associated with a 39%, 22%, 31% and 43% increase in the odds of prevalent MVP/mitral regurgitation, heart failure, atrial fibrillation and ventricular arrhythmias”

   Humansadjusted for age, sex, body mass index, and LV T1papillary musclen = 51,316

   Machine Learning-Enabled Papillary Muscle Fibrosis Assessment in 51,000 Individuals Reveals Independent Links to Cardiac Structure, Function, and Disease and Identifies Genetic Susceptibility Loci

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

More on Ventricular arrhythmias

1. Papillary muscle T1 is associated with atrial fibrillation in humans (31% increase in odds per 100 ms).

   “PM T1 (/100 ms) was significantly associated with a 39%, 22%, 31% and 43% increase in the odds of prevalent MVP/mitral regurgitation, heart failure, atrial fibrillation and ventricular arrhythmias”

   Humansadjusted for age, sex, body mass index, and LV T1papillary musclen = 51,316

   Machine Learning-Enabled Papillary Muscle Fibrosis Assessment in 51,000 Individuals Reveals Independent Links to Cardiac Structure, Function, and Disease and Identifies Genetic Susceptibility Loci

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

More on Atrial fibrillation

1. Papillary muscle T1 is associated with heart failure in humans (22% increase in odds per 100 ms).

   “PM T1 (/100 ms) was significantly associated with a 39%, 22%, 31% and 43% increase in the odds of prevalent MVP/mitral regurgitation, heart failure, atrial fibrillation and ventricular arrhythmias”

   Humansadjusted for age, sex, body mass index, and LV T1papillary musclen = 51,316

   Machine Learning-Enabled Papillary Muscle Fibrosis Assessment in 51,000 Individuals Reveals Independent Links to Cardiac Structure, Function, and Disease and Identifies Genetic Susceptibility Loci

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

More on Heart failure

1. Papillary muscle T1 is associated with mitral valve prolapse in humans (39% increase in odds per 100 ms).

   “PM T1 (/100 ms) was significantly associated with a 39%, 22%, 31% and 43% increase in the odds of prevalent MVP/mitral regurgitation, heart failure, atrial fibrillation and ventricular arrhythmias”

   Humansadjusted for age, sex, body mass index, and LV T1papillary musclen = 51,316

   Machine Learning-Enabled Papillary Muscle Fibrosis Assessment in 51,000 Individuals Reveals Independent Links to Cardiac Structure, Function, and Disease and Identifies Genetic Susceptibility Loci

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

More on Mitral valve prolapse