Urolithiasis

1. Hypertension mediates urolithiasis in humans (10.4%, P = 0.032).

   “hypertension (10.4%, P = 0.032).”

   Humans

   Longitudinal biological aging trajectories and incident urolithiasis: a causal mediation analysis role of metabolic dysfunction in a large Chinese cohort

   Frontiers in endocrinology·Apr 17, 2026

More on Hypertension

1. Obesity mediates urolithiasis in humans (22.9%, P<0.001).

   “Causal mediation analysis confirmed that this association was predominantly driven by BMI (22.9%, P<0.001) and hypertension (10.4%, P = 0.032).”

   Humans

   Longitudinal biological aging trajectories and incident urolithiasis: a causal mediation analysis role of metabolic dysfunction in a large Chinese cohort

   Frontiers in endocrinology·Apr 17, 2026

More on Obesity

1. biological aging trajectories raise the risk of urolithiasis in humans (HR = 1.21, 95% CI: 1.00-1.45, P = 0.047).

   “Compared to the Stable Low-Risk group, the Progressive High-Risk group was associated with an increased risk of lithogenesis in the unadjusted model (HR = 1.21, 95% CI: 1.00-1.45, P = 0.047)”

   Humansunadjusted model

   Longitudinal biological aging trajectories and incident urolithiasis: a causal mediation analysis role of metabolic dysfunction in a large Chinese cohort

   Frontiers in endocrinology·Apr 17, 2026