There are 9 papers on statin intolerance in aging research: 2 trials and 6 observational studies in people, 1 review.
9 papers study it33 more mention it6 findings
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“Among the high- and very-high-risk SI patients, LDL-C goal attainment rates were lower (MT, 19.1%; CT, 22.1%).”
- Human trial2
- Humans6
Effects
3Creatine kinase
upin humans1
1 study
Creatine kinase
upin humans1
Statin intolerance is linked with higher creatine kinase in humans (compared with matched statin-tolerant controls) (p < 0.001).
“Circulating creatine kinase levels, which was higher in SI patients at baseline (p < 0.001), remained higher in those who never restarted statins after re-challenge (p = 0.029).”
Humanscompared with matched statin-tolerant controlsn = 148
Statin-Intolerant Patients Exhibit Diminished Muscle Strength Regardless of Lipid-Lowering Therapy
Journal of clinical medicine
Fat-mass percentage
upin humans1
1 study
Fat-mass percentage
upin humans1
Statin intolerance is linked with higher fat-mass percentage in humans (compared with matched statin-tolerant controls).
“At the end of the follow-up, BIA-assessed fat mass percentage was higher in SI than in ST.”
Humanscompared with matched statin-tolerant controlsmean 45 monthsn = 148
Statin-Intolerant Patients Exhibit Diminished Muscle Strength Regardless of Lipid-Lowering Therapy
Journal of clinical medicine
Handgrip strength
downin humans1
1 study
Handgrip strength
downin humans1
Statin intolerance is linked with worse handgrip strength in humans (compared with matched statin-tolerant controls) (p < 0.001).
“Handgrip absolute values or standardized for skeletal muscle mass (muscle quality) were significantly lower in SI patients (p < 0.001)”
Humanscompared with matched statin-tolerant controlsmean 45 monthsn = 148
Statin-Intolerant Patients Exhibit Diminished Muscle Strength Regardless of Lipid-Lowering Therapy
Journal of clinical medicine
Upstream
1Female sex
no changein humans1OR 1.1
1 study
Female sex
no changein humans1OR 1.1
Female sex was not clearly linked with statin intolerance in humans (OR 1.1, 95% CI 0.9-1.2).
“Women showed a non-significantly higher likelihood of SI (OR, 1.1; 95% CI, 0.9-1.2).”
Humansfemales
Journal of lipid and atherosclerosis
Associations
2LDL-C target achievement
downin humans1
1 study
LDL-C target achievement
downin humans1
Statin intolerance is associated with LDL-C target achievement in humans (High and very high cardiovascular risk) (Monotherapy, 19.1%; combination therapy, 22.1%).
“Among the high- and very-high-risk SI patients, LDL-C goal attainment rates were lower (MT, 19.1%; CT, 22.1%).”
HumansHigh and very high cardiovascular risk
ESC Congress 2026 abstract
Older age
upin humans1OR 1.3
1 study
Older age
upin humans1OR 1.3
Older age is linked with a higher risk of statin intolerance in humans (OR 1.3, 95% CI 1.1-1.4).
“Individuals aged ≥70 years had a higher likelihood of SI (odds ratio [OR], 1.3; 95% confidence interval [CI], 1.1-1.4).”
Humans
Journal of lipid and atherosclerosis