Skeletal muscle wasting

2 papers2 findings

Humans2

Interventions

1

BML-260

downin animals1

1 study

BML-260 prevents skeletal muscle wasting.
“treatment with BML-260 (a small molecule previously reported to target DUSP22) prevented multiple forms of muscle wasting.”
Animalsmodels of skeletal muscle wasting
Modulating phosphatase DUSP22 with BML-260 ameliorates skeletal muscle wasting via Akt independent JNK-FOXO3a repression
EMBO molecular medicine22 Apr 2025

More on BML-260

Upstream

1

DUSP22

upin animals1

1 study

DUSP22 increases skeletal muscle wasting.
“DUSP22 knockdown or treatment with BML-260 (a small molecule previously reported to target DUSP22) prevented multiple forms of muscle wasting.”
Animalsshown by knockdown
Modulating phosphatase DUSP22 with BML-260 ameliorates skeletal muscle wasting via Akt independent JNK-FOXO3a repression
EMBO molecular medicine22 Apr 2025

Latest

2 in 12 months

American Journal of Nephrology21 Aug

The Regulation of CCN1 Contributes to Skeletal Muscle Wasting in Chronic Kidney Disease

Experiments in miceKidney

Journal of Cachexia, Sarcopenia and Muscle5 Feb

Largely Distinct Post-Translational Modifications Differentiate Skeletal Muscle Wasting Caused by Cancer, Dexamethasone and Aging

Experiments in miceMuscle

EMBO Molecular Medicine23 Apr

Modulating phosphatase DUSP22 with BML-260 ameliorates skeletal muscle wasting via Akt independent JNK-FOXO3a repression

Study in peopleJNK signalling

Biogerontology24 Jan

Age, cancer, and the dual burden of cancer and doxorubicin in skeletal muscle wasting in female rats: which one to blame?

Experiments in animalsMechanisms

Antioxidants27 Jul

The Double-Edged Sword of ROS in Muscle Wasting and COPD: Insights from Aging-Related Sarcopenia

ReviewMechanisms

bioRxiv11 Apr

Targeting phosphatase DUSP22 ameliorates skeletal muscle wasting via Akt independent JNK-FOXO3a repression

Preprint: study in peopleJNK signalling

Free Radical Biology & Medicine5 Apr

Mitochondrial remodeling underlying age-induced skeletal muscle wasting: let's talk about sex

Experiments in animalsMechanisms

JCI Insight6 Dec

Senotherapeutic drug treatment ameliorates chemotherapy-induced cachexia

Experiments in animalsInterventions

Life Sciences3 Dec

The contribution of mitochondria to age-related skeletal muscle wasting: A sex-specific perspective

ReviewMechanisms

Physical Activity and Nutrition16 Aug

Effects of aging-induced obesity on the transcriptional expression of adipogenesis and thermogenic activity in the gonadal white adipose, brown adipose, and skeletal muscle tissues

Experiments in animalsMechanisms