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BML-260

Intervention

1 paper2 findings

PubChem

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Institute of Information & Communications Technology Planning & Evaluation and 2 more
  • Humans1

Outcomes

2

Atrophy

downin human cells1

1 study

  1. BML-260 decreases atrophy in human cells.

    “DUSP22 targeting was also effective in human skeletal muscle cells undergoing atrophy.”

    Cellshuman skeletal muscle cells undergoing atrophy

    Modulating phosphatase DUSP22 with BML-260 ameliorates skeletal muscle wasting via Akt independent JNK-FOXO3a repression

    EMBO molecular medicine22 Apr 2025

Skeletal muscle wasting

downin animals1

1 study

  1. BML-260 prevents skeletal muscle wasting.

    “treatment with BML-260 (a small molecule previously reported to target DUSP22) prevented multiple forms of muscle wasting.”

    Animalsmodels of skeletal muscle wasting

    Modulating phosphatase DUSP22 with BML-260 ameliorates skeletal muscle wasting via Akt independent JNK-FOXO3a repression

    EMBO molecular medicine22 Apr 2025

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