DUSP22

1. DUSP22 increases skeletal muscle wasting.

   “DUSP22 knockdown or treatment with BML-260 (a small molecule previously reported to target DUSP22) prevented multiple forms of muscle wasting.”

   Animalsshown by knockdown

   Modulating phosphatase DUSP22 with BML-260 ameliorates skeletal muscle wasting via Akt independent JNK-FOXO3a repression

   EMBO molecular medicine·22 Apr 2025

More on Skeletal muscle wasting

1. DUSP22 increases skeletal muscle cell atrophy in human cells.

   “DUSP22 targeting was also effective in human skeletal muscle cells undergoing atrophy.”

   Cellsshown by DUSP22 targeting in cells undergoing atrophyskeletal muscle cell

   Targeting phosphatase DUSP22 ameliorates skeletal muscle wasting via Akt independent JNK-FOXO3a repression

   bioRxiv (Cold Spring Harbor Laboratory)·11 Apr 2024Preprint