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Severe insulin resistant diabetes

Disease

2 papers4 findings

  • Humans2

Effects

2

HOMA2-B

upin humans1

1 study

  1. Severe insulin resistant diabetes increases HOMA2-B in humans (42.2, 95%CI: 42.1, 42.3).

    “and HOMA2-%B (42.2, 95%CI: 42.1, 42.3).”

    Humansin five years before diagnosis, relative to those without T2D

    Metabolic Trajectories Preceding Diagnosis of Type 2 Diabetes Subtypes in Cohort Studies from the United States

    ADA Scientific Sessions 2025 abstract13 Jun 2025

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HOMA2-IR

upin humans1

1 study

  1. Severe insulin resistant diabetes increases HOMA2-IR in humans (2.2, 95%CI: 2.0, 2.3).

    “SIRD displayed sharp increases in HOMA2-IR (2.2, 95%CI: 2.0, 2.3)”

    Humansin five years before diagnosis, relative to those without T2D

    Metabolic Trajectories Preceding Diagnosis of Type 2 Diabetes Subtypes in Cohort Studies from the United States

    ADA Scientific Sessions 2025 abstract13 Jun 2025

More on HOMA2-IR

Associations

2

Body mass index

upin humans1HR 1.01

1 study

  1. Body mass index is associated with severe insulin resistant diabetes in humans (HR: 1.01 [95%CI: 1.00, 1.03]).

    “higher BMI was associated with MOD (HR: 1.04 [95%CI: 1.04, 1.05]) and SIRD (HR: 1.01 [95%CI: 1.00, 1.03])”

    Humans15 years

    Association of Pathophysiological Markers with Type 2 Diabetes Subtypes

    ADA Scientific Sessions 2025 abstract13 Jun 2025

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HOMA2-IR

upin humans1HR 1.7

1 study

  1. HOMA2-IR is associated with severe insulin resistant diabetes in humans (HR: 1.70 [95%CI: 1.54, 1.89]).

    “Higher HOMA2-IR was associated with membership in SIRD (HR: 1.70 [95%CI: 1.54, 1.89])”

    Humans15 years

    Association of Pathophysiological Markers with Type 2 Diabetes Subtypes

    ADA Scientific Sessions 2025 abstract13 Jun 2025

More on HOMA2-IR

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