Severe insulin-deficient diabetes

1. Severe insulin-deficient diabetes decreases HOMA2-B in humans (-84.5, 95%CI: -84.6, -84.3).

   “decreases in HOMA2-%B (-84.5, 95%CI: -84.6, -84.3)”

   Humansin five years before diagnosis, relative to those without T2D

   Metabolic Trajectories Preceding Diagnosis of Type 2 Diabetes Subtypes in Cohort Studies from the United States

   ADA Scientific Sessions 2025 abstract·13 Jun 2025

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1. Severe insulin-deficient diabetes increases HbA1c in humans (4.6% points, 95%CI: 4.5, 4.8).

   “SIDD displayed sharp increases in HbA1c (4.6% points, 95%CI: 4.5, 4.8)”

   Humansin five years before diagnosis, relative to those without T2D

   Metabolic Trajectories Preceding Diagnosis of Type 2 Diabetes Subtypes in Cohort Studies from the United States

   ADA Scientific Sessions 2025 abstract·13 Jun 2025

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1. Severe insulin-deficient diabetes raises the risk of dementia in humans (HR: 1.55 [1.47-1.64]).

   “Relative to adults without diabetes, SIDD (HR: 1.55 [1.47-1.64]) and MARD (HR: 1.10 [1.05-1.14]) had elevated rates of dementia”

   Humansrelative to adults without diabetes

   Type 2 Diabetes Heterogeneity and Incident Dementia Risk Compared with Adults without Diabetes

   ADA Scientific Sessions 2026 abstract·5 Jun 2026

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1. HbA1c is associated with severe insulin-deficient diabetes in humans (HR: 1.21 [95%CI: 0.73, 1.99]).

   “higher HbA1c was associated with SIDD (HR: 1.21 [95%CI: 0.73, 1.99])”

   Humans15 years

   Association of Pathophysiological Markers with Type 2 Diabetes Subtypes

   ADA Scientific Sessions 2025 abstract·13 Jun 2025

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