Severe hypoglycemia

1. Continuous glucose monitoring has no effect on severe hypoglycemia in humans (aHR 0.92, 95% CI 0.77, 1.10).

   “The aHR for SH was comparable between the two groups (aHR 0.92; 95% CI 0.77, 1.10 for users vs non-users).”

   Humanstype 1 diabetes receiving intensive insulin therapy

   Continuous glucose monitoring and risks of acute and chronic diabetes-related complications and mortality in adults with type 1 diabetes: a nationwide cohort study

   Diabetologia·Mar 21, 2026

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1. Severe hypoglycemia is associated with processing Speed Index score change in humans (b = -6.73; 95% CI -12.23 to -1.24).

   “interval severe hypoglycemia predicted 1-year cognitive decline detectable with brief cognitive screening and processing speed measures”

   Humansolder adults with type 1 diabetes; interval severe hypoglycemia1 year47% femalesn = 74

   Determinants of Cognitive Change Over 1 Year in Older Adults With Type 1 Diabetes

   Diabetes, obesity, and cardiometabolic CARE·Aug 28, 2026

1. Hormone replacement therapy lowers the risk of severe hypoglycemia in humans.

   “postmenopausal hormone replacement therapy (HRT) were associated with significantly reduced risk of severe hypoglycemia.”

   Reviewin diabetic womenfemales

   Risk of Hypoglycemia in Diabetes Mellitus in Relation to Testosterone Levels in Men and Estradiol Levels in Women: A Systematic Review

   Zenodo (CERN European Organization for Nuclear Research)·Jul 14, 2026Preprint

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1. Sulfonylureas raise the risk of severe hypoglycemia in humans (highest risk for SU).

   “Hypoglycemia was rare with the highest risk for SU.”

   Humansadded to metformin in patients with T2DM, age ≥30 years, baseline HbA1c 6-9%

   Comparative Glycemic Effectiveness of Four Second-Line Glucose-Lowering Medications in Type 2 Diabetes Mellitus

   ADA Scientific Sessions 2025 abstract·Jun 13, 2025

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1. Severe hypoglycemia is associated with falls in humans (adjusted prevalence ratio = 1.7 (95% CI, 1.3-2.2)).

   “Severe hypoglycemia was associated with a 70% greater prevalence of falls (adjusted prevalence ratio = 1.7 (95% CI, 1.3-2.2)).”

   Humansdiabetespast 12 monthsn = 2,158

   Severe hypoglycemia and falls in older adults with diabetes: The Diabetes & Aging Study

   Diabetes epidemiology and management·Jul 18, 2023

1. End-stage renal disease raises the risk of severe hypoglycemia in humans.

   “Risk factors for severe hypoglycemia included younger and older age, prior severe hypoglycemia, use of insulin, sulfonylurea, two-drug therapy including sulfonylurea or glinides, three-or-more-drug therapy, excessive polypharmacy, and comorbidities including end-stage renal disease (ESRD) requiring dialysis.”

   Humansin patients with type 2 diabetes using glucose-lowering drugsn = 93,801

   Multimorbidity, Polypharmacy, Severe Hypoglycemia, and Glycemic Control in Patients Using Glucose-Lowering Drugs for Type 2 Diabetes: A Retrospective Cohort Study Using Health Insurance Claims in Japan

   Diabetes therapy : research, treatment and education of diabetes and related disorders·May 17, 2023

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1. Sulfonylurea raises the risk of severe hypoglycemia in humans.

   “Risk factors for severe hypoglycemia included younger and older age, prior severe hypoglycemia, use of insulin, sulfonylurea, two-drug therapy including sulfonylurea or glinides, three-or-more-drug therapy, excessive polypharmacy, and comorbidities including end-stage renal disease (ESRD) requiring dialysis.”

   Humansin patients with type 2 diabetes using glucose-lowering drugsn = 93,801

   Multimorbidity, Polypharmacy, Severe Hypoglycemia, and Glycemic Control in Patients Using Glucose-Lowering Drugs for Type 2 Diabetes: A Retrospective Cohort Study Using Health Insurance Claims in Japan

   Diabetes therapy : research, treatment and education of diabetes and related disorders·May 17, 2023

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1. Insulin raises the risk of severe hypoglycemia in humans.

   “Risk factors for severe hypoglycemia included younger and older age, prior severe hypoglycemia, use of insulin, sulfonylurea, two-drug therapy including sulfonylurea or glinides, three-or-more-drug therapy, excessive polypharmacy, and comorbidities including end-stage renal disease (ESRD) requiring dialysis.”

   Humansin patients with type 2 diabetes using glucose-lowering drugsn = 93,801

   Multimorbidity, Polypharmacy, Severe Hypoglycemia, and Glycemic Control in Patients Using Glucose-Lowering Drugs for Type 2 Diabetes: A Retrospective Cohort Study Using Health Insurance Claims in Japan

   Diabetes therapy : research, treatment and education of diabetes and related disorders·May 17, 2023

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1. SGLT2 inhibitors lower the risk of severe hypoglycemia in humans (HR 0.75 [0.68, 0.83]; RD -3.21 [-4.29, -2.12]).

   “SGLT2i was associated with a reduced risk of hypoglycemia versus DPP-4i (HR 0.75 [0.68, 0.83]; RD -3.21 [-4.29, -2.12])”

   Humanstype 2 diabetesmedian 7 months

   Risk of Severe Hypoglycemia With Newer Second-line Glucose-lowering Medications in Older Adults With Type 2 Diabetes Stratified by Known Indicators of Hypoglycemia Risk

   The journals of gerontology. Series A, Biological sciences and medical sciences·Mar 4, 2023

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1. Dementia raises the risk of severe hypoglycemia in humans.

   “patients with dementia and diabetes appear to be at greater risk for severe hypoglycemia”

   Reviewin patients with dementia and diabetes

   Diabetes, Dementia and Hypoglycemia

   Canadian journal of diabetes·Jan 6, 2016

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