HbA1c <7%

There are 3 papers on HbA1c <7% in aging research: 3 observational studies in people.

Biomarker

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“Titration to SEMA 2mg was noninferior (margin: 0.93), but not superior (margin: 1.07), in achieving HbA1c <7% (hazard ratio [HR]: 0.98; 95% CI: 0.94-1.02).”
Cardiometabolic Outcomes in Adults with T2D Treated with 1 mg Semaglutide Who Titrate to 2 mg Semaglutide vs. Switch to TirzepatideADA Scientific Sessions 2026 abstract2026doi:10.2337/db26-2834-lb
  • Humans3

Associations

5

SGLT2 inhibitors

no changein humans1OR 0.56

1 study
  1. SGLT2 inhibitors are associated with HbA1c <7% in humans (Adjusted OR 0.56 (95% CI 0.20–1.58); P = .274; association not significant).

    “SGLT2 inhibitor use was not significant after adjustment”

    HumansAdults with type 2 diabetes attending specialized cardiology outpatient care; exploratory multivariable adjustment71.7% malesn = 138

    Cardiovascular risk profile and treatment patterns in patients with type 2 diabetes in specialized cardiology outpatient care in Colombia: A retrospective cross-sectional study

    Medicine

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Absence of prespecified echocardiographic abnormalities

downin humans1OR 0.36

1 study
  1. Absence of prespecified echocardiographic abnormalities are associated with HbA1c <7% in humans (Adjusted OR 0.36 (95% CI 0.15–0.88); P = .026).

    “the absence of prespecified echocardiographic abnormalities was inversely associated”

    HumansAdults with type 2 diabetes attending specialized cardiology outpatient care; exploratory multivariable adjustment71.7% malesn = 138

    Cardiovascular risk profile and treatment patterns in patients with type 2 diabetes in specialized cardiology outpatient care in Colombia: A retrospective cross-sectional study

    Medicine

Total cholesterol

upin humans1

1 study
  1. Total cholesterol is associated with HbA1c <7% in humans (Adjusted OR per 10 mg/dL 1.10 (95% CI 1.01–1.20); P = .033).

    “total cholesterol was associated with HbA1c >7%”

    HumansAdults with type 2 diabetes attending specialized cardiology outpatient care; exploratory multivariable adjustment71.7% malesn = 138

    Cardiovascular risk profile and treatment patterns in patients with type 2 diabetes in specialized cardiology outpatient care in Colombia: A retrospective cross-sectional study

    Medicine

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Semaglutide

no changein humans1HR 0.98

1 study
  1. Semaglutide is associated with HbA1c <7% in adults with T2D previously treated with 1 mg semaglutide (HR 0.98, 95% CI 0.94-1.02).

    “Titration to SEMA 2mg was noninferior (margin: 0.93), but not superior (margin: 1.07), in achieving HbA1c <7% (hazard ratio [HR]: 0.98; 95% CI: 0.94-1.02).”

    Humansin adults with T2D previously treated with 1 mg semaglutide

    Cardiometabolic Outcomes in Adults with T2D Treated with 1 mg Semaglutide Who Titrate to 2 mg Semaglutide vs. Switch to Tirzepatide

    ADA Scientific Sessions 2026 abstract

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GLP-1 receptor agonists

downin humans1HR 0.63

1 study
  1. GLP-1 receptor agonists are linked with a lower risk of HbA1c <7% in humans (added to metformin in patients with T2DM, age ≥30 years, baseline HbA1c 6-9%) (HR 0.63; 0.58-0.68 vs. SGLT-2i).

    “GLP-1RA had the lowest risk of primary outcome (HR 0.63;0.58-0.68, HR 0.71;0.65-0.76, and HR 0.67;0.61-0.72 vs. SGLT-2i, SU, and DPP-4i, respectively).”

    Humansadded to metformin in patients with T2DM, age ≥30 years, baseline HbA1c 6-9%

    Comparative Glycemic Effectiveness of Four Second-Line Glucose-Lowering Medications in Type 2 Diabetes Mellitus

    ADA Scientific Sessions 2025 abstract

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