Post-operative cognitive dysfunction

1. Buprenorphine showed no clear effect on post-operative cognitive dysfunction in rats (tibial fracture surgery model of POCD).

   “but not in animals which were exposed to anesthesia alone or underwent the surgery and received buprenorphine”

   Animalstibial fracture surgery model of POCD

   Paracetamol (acetaminophen) as potential first-choice analgesic in post-operative cognitive decline (POCD): Behavioral and molecular evidence in a middle-aged rat model

   Research Square·Dec 18, 2020Preprint

More on Buprenorphine

1. Acetaminophen prevents post-operative cognitive dysfunction in rats (tibial fracture surgery model of POCD).

   “cognitive decline and increased allodynia following surgery was prevented in paracetamol-treated animals”

   Animalstibial fracture surgery model of POCD

   Paracetamol (acetaminophen) as potential first-choice analgesic in post-operative cognitive decline (POCD): Behavioral and molecular evidence in a middle-aged rat model

   Research Square·Dec 18, 2020Preprint

More on Acetaminophen

1. Minocycline decreases post-operative cognitive dysfunction in mice (isoflurane exposure or surgery).

   “pre-treatment with MINO attenuated isoflurane or surgery induced cognitive impairment”

   Animalsisoflurane exposure or surgery

   Minocycline attenuates post-operative cognitive impairment in aged mice by inhibiting microglia activation

   Journal of cellular and molecular medicine·Apr 6, 2016

More on Minocycline

1. Body weight showed no clear effect on post-operative cognitive dysfunction in humans (body weight analysed continuously) (RR 0.99 per kg (95% CI 0.89–1.09)).

   “relative risk 0.99 per kg; 95% confidence interval 0.89, 1.09; p = 0.83”

   Reviewbody weight analysed continuouslyper kg

   Obesity and post-operative cognitive dysfunction: a systematic review and meta-analysis

   Diabetes/metabolism research and reviews·Feb 19, 2016

More on Body weight

1. Body mass index showed no clear effect on post-operative cognitive dysfunction in humans (BMI analysed continuously) (RR 0.98 per kg/m2 (95% CI 0.93–1.03)).

   “relative risk 0.98 per kg/m(2) ; 95% confidence interval 0.93, 1.03, p = 0.45”

   ReviewBMI analysed continuouslyper kg/m2

   Obesity and post-operative cognitive dysfunction: a systematic review and meta-analysis

   Diabetes/metabolism research and reviews·Feb 19, 2016

More on Body mass index