Buprenorphine

Buprenorphine has been studied in 3 papers since 2017: 1 trial in people, 2 in animals. The newest paper, Nov 2, 2021: “Establishment of a Novel Method for Spinal Discectomy Surgery in Elderly Rats in an In Vivo Spinal Fusion Model”.

Intervention

3 papers study it6 more mention it2 findingsUpdated Nov 2, 2021

PubChem ChEBI MeSH

See all 9

“We found a significant increase in TST for patients who received active buprenorphine compared with those who received active paracetamol (see Table ).”

Effects of pain treatment on sleep in nursing home patients with dementia and depression: A multicenter placebo-controlled randomized clinical trialInternational journal of geriatric psychiatry2017doi:10.1002/gps.4839

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

About aging: trials about aging, of every trial that tests the drug for any use.

No results posted: trials that ended over a year ago with no results on ClinicalTrials.gov and no paper reporting them.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 3 countries
8 trials, none about aging, 1 with no results posted

Funders: GC Rieber Fondene and 5 more
1 of 2 findings with company ties

Human trial1
Animals2

Studies in people

1 study gave buprenorphine to people and measured what changed.

up: Increases total sleep time
Randomized trial106 people 76% were female mean age was 85.5 years (SD = 7.3)1 week
Nursing home patients with dementia and depression
International journal of geriatric psychiatry, Dec 28, 2017

What did studies of Buprenorphine find?

Studies of Buprenorphine measured 2 outcomes; the most studied are post-operative cognitive dysfunction (1 study) and total sleep time (1).

Post-operative cognitive dysfunction

no changein rats1

1 study

Buprenorphine showed no clear effect on post-operative cognitive dysfunction in rats (tibial fracture surgery model of POCD).
“but not in animals which were exposed to anesthesia alone or underwent the surgery and received buprenorphine”
Animalstibial fracture surgery model of POCD
Paracetamol (acetaminophen) as potential first-choice analgesic in post-operative cognitive decline (POCD): Behavioral and molecular evidence in a middle-aged rat model
Research SquareDec 18, 2020Preprint

More on Post-operative cognitive dysfunction

Total sleep time

upin humans1

1 study

Buprenorphine increases total sleep time in humans (compared with active paracetamol).
“We found a significant increase in TST for patients who received active buprenorphine compared with those who received active paracetamol (see Table ).”
Human trialcompared with active paracetamol1 week
Effects of pain treatment on sleep in nursing home patients with dementia and depression: A multicenter placebo-controlled randomized clinical trial
International journal of geriatric psychiatryDec 28, 2017