Neuroinflammatory disease
Upstream
1Glycolysis
downin reviews1
1 study
Glycolysis
downin reviews1
Glycolysis protects against neuroinflammatory disease.
“increasing glycolytic flux through pharmacological or genetic manipulation of glycolytic enzymes, has shown potential protective effects in several animal models of neuroinflammatory diseases”
Reviewanimal models of neuroinflammatory diseases
Ageing research reviewsSep 2, 2024
Trial sponsors
University of California, San Diego
1 trialPhase 290 people
Latest
2 in 12 monthsJournal of Neuroinflammation
Senolytic treatment diminishes microglia and decreases severity of experimental autoimmune encephalomyelitis
Experiments in miceSenolytics
Nature Communications
The aging mouse CNS is protected by an autophagy-dependent microglia population promoted by IL-34
Experiments in miceAutophagy
EMBO Molecular Medicine
Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain
Experiments in animalsInterventions
Communications Biology
CCR3 plays a role in murine age-related cognitive changes and T-cell infiltration into the brain
Experiments in animalsMechanisms
Immunity & Ageing
Composition of the infiltrating immune cells in the brain of healthy individuals: effect of aging
Computational studyMechanisms
Trends in Molecular Medicine
Cellular senescence in neuroinflammatory disease: new therapies for old cells?
ReviewMechanisms