Nephrolithiasis
Disease1 paper1 finding
Associations
1SGLT2 inhibitors
downin humans1OR 0.72Moderate certainty
1 study
SGLT2 inhibitors
downin humans1OR 0.72Moderate certainty
SGLT2 inhibitors lower the risk of nephrolithiasis in humans (OR 0.72, 95% CI 0.65-0.80).
Reviewadults with type 2 diabetes
SGLT2 Inhibitors and Nephrolithiasis Risk in Adults With Type 2 Diabetes: A Systematic Review and Meta-analysis · Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 29 Sep 2026