Macular degeneration
Disease1 paper
- In silico1
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7Vitamin D deficiency links to intermediate macular degeneration
Deficiency (<25 nmol/l) was associated with incident intermediate AMD with a hazard ratio of 2.34 compared to sufficient levels (≥50 nmol/l).Deficiency (<25 nmol/l) was associated with incident intermediate AMD with a hazard ratio of 2.34 compared to sufficient levels (≥50 nmol/l).
Membrane attack complex deposits on pericytes in human eyes
Single-cell analysis of four aged human donor eyes revealed complement membrane attack complexes concentrated primarily on pericytes, smooth muscle…Single-cell analysis of four aged human donor eyes revealed complement membrane attack complexes concentrated primarily on pericytes, smooth muscle cells, and macrophages.
PFAS exposures link to glaucoma and cataract risks
An analysis of 2005–2008 NHANES data, Mendelian randomization, and cell assays linked PFOS exposure to glaucoma risk through PI3K/Akt signaling.An analysis of 2005–2008 NHANES data, Mendelian randomization, and cell assays linked PFOS exposure to glaucoma risk through PI3K/Akt signaling.
Genetically proxied CETP inhibition links to higher AMD risk
In drug-target Mendelian randomization, proxied CETP inhibition was associated with advanced AMD in Europeans (OR 1.45) and exudative AMD in East…In drug-target Mendelian randomization, proxied CETP inhibition was associated with advanced AMD in Europeans (OR 1.45) and exudative AMD in East Asians (OR 3.14).