Lymph node metastasis

3 papers1 finding

Human trial1
Humans2

Upstream

1

Cellular senescence

upin human cells1

1 study

Cellular senescence increases lymph node metastasis in human cells.
“senescent cancer-associated fibroblasts (senCAF) drive lymphatic remodeling and LNM in early-stage PDAC”
Cellsin early-stage PDAC
Senescent Cancer-Associated Fibroblasts Drive Early-Stage Lymph Node Metastasis in Pancreatic Cancer through Lactate-Mediated Metabolic-Epigenetic Rewiring
Cancer discovery27 Mar 2026

More on Cellular senescence

Trial sponsors

Johannes Gutenberg University Mainz
1 trialPhase 3209 people

Latest

2 in 12 months

Cancer Discovery27 Mar

Senescent Cancer-Associated Fibroblasts Drive Early-Stage Lymph Node Metastasis in Pancreatic Cancer through Lactate-Mediated Metabolic-Epigenetic Rewiring

Non-randomised trial in peoplePancreatic cancer

Oncology Reports5 Dec

Prognostic significance of fibroblast senescence and senescence-associated secretory phenotype factor expression in the tumor microenvironment of pancreatic ductal adenocarcinoma

Cohort study of 90 peopleSenescence-associated secretory phenotype (SASP)

Preventive Medicine Reports27 Oct

Breast cancer screening in women aged 75 and older: Insights from an aging region in Japan

Cohort study of 289 peopleBreast cancer