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HAPLN1

Gene

3 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: National Cancer Institute and 3 more
  • Animals3

Effects

3

Skin extracellular matrix

downin reviews1

1 study

  1. HAPLN1 impairs skin extracellular matrix.

    “Its serum levels decreased with age, disturbing the integrity of the skin extracellular matrix”

    Reviewaging

    Hyaluronan and proteoglycan link protein 1 - A novel signaling molecule for rejuvenating aged skin

    Matrix biology : journal of the International Society for Matrix BiologySep 1, 2024

ICAM1

downin mice1

1 study

  1. HAPLN1 decreases ICAM1 in mice.

    “HAPLN1 in the ECM increases hyaluronic acid and decreases endothelial cell expression of ICAM1”

    Animalsin the ECMendothelial cell

    Age-dependent loss of HAPLN1 erodes vascular integrity via indirect upregulation of endothelial ICAM1 in melanoma

    Nature agingMar 12, 2024

More on ICAM1

Vascular integrity

upin mice1

1 study

  1. HAPLN1 improves vascular integrity in mice.

    “HAPLN1 in the dermal ECM is sufficient to maintain the integrity of melanoma-associated blood vessels”

    Animalsmelanoma-associated blood vessels

    Age-dependent loss of HAPLN1 erodes vascular integrity via indirect upregulation of endothelial ICAM1 in melanoma

    Nature agingMar 12, 2024

Funding

1 grant since 2021

National Cancer InstituteUS$42.5k

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