Lumbar fracture

Disease1 paper2 findings

  • Humans1

Upstream

1

Bone mineral density

mediatesin humans1

1 study

  1. Bone mineral density mediates lumbar fracture in humans (64.8%).

    Humansmediating 64.8% of SHBG's effect on LF

    Sex hormone-binding globulin raises lumbar fracture risk · Medicine · 2 Oct 2026

Bone mineral density →

Associations

1

SHBG

upin humans1OR 1.201

1 study

  1. SHBG raises the risk of lumbar fracture in humans (OR 1.201, 95% CI 1.028-1.404).

    HumansFinnGen

    Sex hormone-binding globulin raises lumbar fracture risk · Medicine · 2 Oct 2026

SHBG →

Latest

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MedicineHumans

Sex hormone-binding globulin raises lumbar fracture risk

Genetically higher SHBG increased lumbar fracture risk with an odds ratio of 1.201 in FinnGen and 1.005 in UK Biobank, mediated primarily by bone…Genetically higher SHBG increased lumbar fracture risk with an odds ratio of 1.201 in FinnGen and 1.005 in UK Biobank, mediated primarily by bone density.

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