Laryngeal and hypopharyngeal squamous cell carcinoma

Disease1 paper1 finding

  • Humans1

Associations

1

5alpha-reductase inhibitors

downin humans1HR 0.83Low certainty

1 study

  1. 5alpha-reductase inhibitors lower the risk of laryngeal and hypopharyngeal squamous cell carcinoma in humans (-17% (adjusted HR 0.83, 95% CI 0.72-0.96)).

    Humanscompared to nonusersmales

    5-ARI use is tied to lower laryngeal cancer risk in men · JAMA otolaryngology-- head & neck surgery · 1 Oct 2026

5alpha-reductase inhibitors →

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JAMA Otolaryngology-- Head & Neck SurgeryHumans

5-ARI use is tied to lower laryngeal cancer risk in men

In a Swedish cohort, 5-ARI users had a 17% lower risk of laryngeal or hypopharyngeal squamous cell carcinoma than nonusers (adjusted hazard ratio…In a Swedish cohort, 5-ARI users had a 17% lower risk of laryngeal or hypopharyngeal squamous cell carcinoma than nonusers (adjusted hazard ratio, 0.83).

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