Incident cancer

1. GAGome score predicts incident cancer in humans (Healthy asymptomatic adults) (HR 1.66, 95% CI 1.60–1.73 per standard deviation increase).

   “A standard deviation increase in the GAGome score was associated with a significantly elevated risk of incident cancer”

   HumansHealthy asymptomatic adultsPer standard deviation increase in GAGome scoreFive yearsn = 5,436

   Urine profile linked to future cancer risk in healthy adults

   Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology·Nov 6, 2026

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1. Regularly distributed physical activity is associated with incident cancer in humans (Individuals with CHIP; compared with inactive participants) (HR 0.78, 95% CI 0.58–1.05; not statistically significant).

   “the association for active regular participants was not statistically significant (HR = 0.78, 95% CI: 0.58–1.05)”

   HumansIndividuals with CHIP; compared with inactive participants≥150 min/week but not meeting WW criteria

   Associations between Physical Activity Patterns and Incident Cancers in Individuals with Clonal Hematopoiesis of Indeterminate Potential

   Frontiers in oncology·Oct 30, 2026

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1. Weekend warrior physical activity is associated with incident cancer in humans (Individuals with CHIP; compared with inactive participants) (HR 0.67, 95% CI 0.52–0.86).

   “the active WW pattern was associated with a reduced cancer hazard (HR = 0.67, 95% CI: 0.52–0.86)”

   HumansIndividuals with CHIP; compared with inactive participants≥150 min/week with ≥50% accumulated in 1–2 days

   Associations between Physical Activity Patterns and Incident Cancers in Individuals with Clonal Hematopoiesis of Indeterminate Potential

   Frontiers in oncology·Oct 30, 2026

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1. Moderate-to-vigorous physical activity is associated with incident cancer in humans (Individuals with CHIP; compared with inactive participants) (HR 0.71, 95% CI 0.56–0.89).

   “Compared to inactive participants, active individuals exhibited a significantly lower hazard of overall cancer”

   HumansIndividuals with CHIP; compared with inactive participants≥150 min/week

   Associations between Physical Activity Patterns and Incident Cancers in Individuals with Clonal Hematopoiesis of Indeterminate Potential

   Frontiers in oncology·Oct 30, 2026

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1. HbA1c is associated with incident cancer in humans (Concurrent heart failure and type 2 diabetes mellitus; HbA1c <5.0% versus 5.0–6.9%) (aHR 1.28, 95% CI 1.15–1.43).

   “for incident cancer were 1.28 (1.15–1.43) for HbA1c <5.0%, 1.19 (1.08–1.31) for HbA1c 7.0–8.9%, and 1.37 (1.23–1.53) for HbA1c ≥9.0%”

   HumansConcurrent heart failure and type 2 diabetes mellitus; HbA1c <5.0% versus 5.0–6.9%Median follow-up of 4.8 years58.4% malesn = 62,845

   Blood sugar marker tied to cancer in heart failure and type 2 diabetes

   ESC Congress 2026 abstract·Oct 26, 2026

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1. XGBoost model predicts incident cancer in humans (heart failure; internal held-out test sets) (AUROC 0.795, 95% CI 0.789–0.801).

   “0.795 (95% CI 0.789–0.801) for the all types of cancer outcome”

   Humansheart failure; internal held-out test sets

   Prediction and personalized interpretation of risk for multiple cancer outcomes in patients with heart failure: a machine learning study

   ESC Congress 2026 abstract·Oct 26, 2026

1. C-reactive protein is associated with incident cancer in humans (Excluding nonmelanoma skin cancers; free of cancer and cardiovascular disease at baseline).

   “Whereas NT-proBNP, UAE, and hsCRP were significantly associated with incident CVD, only hsCRP was significantly associated with incident cancer.”

   HumansExcluding nonmelanoma skin cancers; free of cancer and cardiovascular disease at baseline12 yearsn = 7,755

   Differential associations of cardiorenal-inflammatory markers with incident cardiovascular disease and cancer in the general population

   ESC Congress 2026 abstract·Oct 26, 2026

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1. Plasma proteins are associated with incident cancer in humans (CKD; no prior cancer) (12 proteins significant after false discovery rate correction).

   “Plasma proteomics identified 12 proteins associated with future cancer in CKD.”

   HumansCKD; no prior cancerplasmaMedian 5.5 years45% femalesn = 2,975

   Plasma Proteomics of Cancer Risk Among Patients with CKD

   Kidney360·Oct 23, 2026

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1. Antimony is associated with incident cancer in humans (Single-metal model; not significant after FDR correction (p = 0.133)) (OR 1.72, 95% CI 1.13–2.63 per interquartile-range increase; FDR-adjusted p = 0.133).

   “Single-metal models showed higher cancer odds with nickel (OR 1.63, 95% CI 1.08-2.45) and antimony (OR 1.72, 95% CI 1.13-2.63) per interquartile-range increase;”

   HumansSingle-metal model; not significant after FDR correction (p = 0.133)hairPer interquartile-range increase3 yearsn = 2,120

   Hair trace metal concentrations and cancer incidence in Mexico: A 3-year prospective analysis of the Mexican Health and Aging Study

   Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)·Oct 15, 2026

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1. Nickel is associated with incident cancer in humans (Mutually adjusted metal model in adults in Mexico) (OR 1.60, 95% CI 1.03–2.56).

   “after mutual adjustment, only nickel remained associated with cancer (OR 1.60, 95% CI 1.03-2.56).”

   HumansMutually adjusted metal model in adults in Mexicohair3 yearsn = 2,120

   Hair trace metal concentrations and cancer incidence in Mexico: A 3-year prospective analysis of the Mexican Health and Aging Study

   Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)·Oct 15, 2026

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