There are 2 papers on Gremlin 2 in aging research: 1 trial and 1 observational study in people.
2 papers study it1 more mentions it8 findings
1 new paper in 30 daysSee all 3 papers on Gremlin 2
“Fasting Grem2 levels were lower in participants with T2D compared with those without T2D (728 ± 25 vs. 649 ± 31 pg/mL, p = 0.020), with an even more pronounced reduction observed at 1 h (631 ± 26 vs. 537 ± 31 pg/mL, p = 0.007).”
- Human trial1
- Humans1
Interventions
2Caloric restriction
upin humans1
1 study
Caloric restriction
upin humans1
Caloric restriction increases Gremlin 2 in humans (1118 ± 89 vs. 1144 ± 90 vs. 1253 ± 89 pg/mL).
“However, calorie restriction resulted in an increase in 1‐h (1118 ± 89 vs. 1144 ± 90 vs. 1253 ± 89 pg/mL, p = 0.002 for trend) and 2‐h Grem2 levels (1067 ± 71 vs. 1186 ± 72 vs. 1144 ± 72 pg/mL, p = 0.008 for trend).”
Human trialn = 231
Journal of diabetes
Caloric restriction increases Gremlin 2 in participants with prediabetes (1118 ± 89 vs. 1144 ± 90 vs. 1253 ± 89 pg/mL, p for trend = 0.002).
“1-h Grem2 levels increased following calorie restriction (1118 ± 89 vs. 1144 ± 90 vs. 1253 ± 89 pg/mL, p for trend = 0.002)”
Human trialin participants with prediabetesn = 231
Journal of diabetes
Oral antidiabetic drugs
upin humans1
1 study
Oral antidiabetic drugs
upin humans1
Oral antidiabetic drugs increase Gremlin 2 in humans (550 ± 12 vs. 575 ± 12 pg/mL).
“Despite the availability of only fasting samples for Grem2 measurement, a significant elevation in fasting Grem2 levels was detected at the end of 3‐month antidiabetic treatment (550 ± 12 vs. 575 ± 12 pg/mL, p = 0.019), alongside enhancements in both oral DI and HOMA‐β among the participants.”
Human trialn = 67
Journal of diabetes
Oral antidiabetic drugs increase Gremlin 2 in participants with T2D (550 ± 12 vs. 575 ± 12 pg/mL, p = 0.019).
“Fasting Grem2 levels were restored after antidiabetic treatment (550 ± 12 vs. 575 ± 12 pg/mL, p = 0.019)”
Human trialin participants with T2Dn = 67
Journal of diabetes
Associations
2β-cell function
upin humans1
1 study
β-cell function
upin humans1
Gremlin 2 is associated with β-cell function in humans (β = 0.12).
“The 1‐h Grem2 levels were positively associated with both oral DI (β = 0.12, p = 0.039) and HOMA‐β (β = 0.15, p = 0.030).”
Human trialn = 178
Journal of diabetes
Gremlin 2 is associated with β-cell function in humans across all trials.
“The 1-h Grem2 levels were positively associated with β-cell function assessed by the oral disposition index and HOMA-β.”
Humansacross all trials
Journal of diabetes
Type 2 diabetes
downin humans1
1 study
Type 2 diabetes
downin humans1
Type 2 diabetes is associated with Gremlin 2 in humans (728 ± 25 vs. 649 ± 31 pg/mL).
“Fasting Grem2 levels were lower in participants with T2D compared with those without T2D (728 ± 25 vs. 649 ± 31 pg/mL, p = 0.020), with an even more pronounced reduction observed at 1 h (631 ± 26 vs. 537 ± 31 pg/mL, p = 0.007).”
Human trialn = 178
Journal of diabetes
Type 2 diabetes is associated with Gremlin 2 in humans (type 2 diabetes vs without type 2 diabetes) (728 ± 25 vs. 649 ± 31 pg/mL, p = 0.020; 631 ± 26 vs. 537 ± 31 pg/mL, p = 0.007).
“Fasting and 1-h Grem2 levels were lower in participants with T2D compared with those without T2D”
Humanstype 2 diabetes vs without type 2 diabetes
Journal of diabetes