Hypertrophic scar

1. PhenoAge is associated with hypertrophic scar in humans (OR 0.911, 95% CI 0.848–0.979; nominal P=0.011).

   “higher PhenoAge (OR=0.911, 95% CI: 0.848-0.979, P=0.011) were nominally associated with a decreased risk of HS.”

   HumansGenetically predicted higher PhenoAge; nominal association replicated independently but not significant after false discovery rate correction

   Genetically Proxied Biological Aging and Risk of Hypertrophic Scar/Keloid-Coded Phenotypes: An Exploratory Two-Sample Mendelian Randomization Study

   Clinical, cosmetic and investigational dermatology·14 Jul 2026

2. PhenoAge lowers the risk of hypertrophic scar in silico.

   “whereas PhenoAge exhibited negative correlations”

   In silicogenetic association (MR)

   Deciphering the Causal Links Among Metabolomics, Ageing Phenotypes, and Pathological Scars: A Two-Sample Mendelian Randomization Study

   Clinical, cosmetic and investigational dermatology·11 May 2026

More on PhenoAge

1. Intrinsic epigenetic age acceleration is associated with hypertrophic scar in humans (OR 0.926, 95% CI 0.878–0.976; nominal P=0.004).

   “Genetically predicted higher IEAA (Odds Ratio [OR]=0.926, 95% Confidence Interval [CI]: 0.878-0.976, P=0.004)”

   HumansGenetically predicted higher IEAA; nominal association, not significant after false discovery rate correction

   Genetically Proxied Biological Aging and Risk of Hypertrophic Scar/Keloid-Coded Phenotypes: An Exploratory Two-Sample Mendelian Randomization Study

   Clinical, cosmetic and investigational dermatology·14 Jul 2026

More on Intrinsic epigenetic age acceleration

1. Telomere length raises the risk of hypertrophic scar in silico.

   “telomere length showed positive correlations with both scar types”

   In silicogenetic association (MR)

   Deciphering the Causal Links Among Metabolomics, Ageing Phenotypes, and Pathological Scars: A Two-Sample Mendelian Randomization Study

   Clinical, cosmetic and investigational dermatology·11 May 2026

More on Telomere length