Hepatoma

3 papers study it20 more mention it2 findings

Animals3

Associations

2

2-mercaptoethylamine + ethoxyquin

upin mice1

1 study

2-mercaptoethylamine + ethoxyquin raises the risk of hepatoma in mice.
“Hepatic degeneration and increased hepatoma in the R+ alpha ox group suggested unusual hepatotoxicity of this regimen.”
Animalscombined with dietary caloric restrictionliver
Dietary restriction alone and in combination with oral ethoxyquin/2-mercaptoethylamine in mice
Journal of gerontologySep 1, 1990

More on 2-mercaptoethylamine + ethoxyquin

Splenomegaly

upin mice1

1 study

Hepatoma is associated with splenomegaly in mice.
“It was possible to associate this splenomegaly with the appearance of gross and microscopic evidence of hepatomas.”
Animalsspleenmales
The incidence, pathology and transplantation of hepatomas in CBA mice
The Journal of pathologyAug 1, 1976

Trial sponsors

Boston Scientific
Company1 trialPhase 32 people
Traws Pharma
Company1 trialPhase 116 people
Yale University
1 trialPhase 250 people
National Cancer Institute
1 trialPhase 1/227 people

Latest

2 papers in 12 months

Frontiers in PharmacologyJun 10

Pharmacological profiling of intravenous MP-04: sustained NAD⁺ augmentation, immune modulation, and renal protection in preclinical models

Experiments in miceKidney

Journal of Gastroenterology and HepatologyMar 26

IL-15 Plus Thymosin α1 Reduces Senescent Hepatic CD8⁺ T Cells in Hepatocellular Carcinoma via PI3K/AKT Suppression

Experiments in miceHepatocellular carcinoma

Discover OncologyJun 10

Suppression of MRPL23 induces cellular senescence in hepatocellular carcinoma by targeting HMGB1

Experiments in miceCellular senescence

Journal of Physiology and BiochemistrySep 18

Palmitic acid causes hepatocyte inflammation by suppressing the BMAL1-NAD⁺-SIRT2 axis

Study in peopleInterventions

Cell ReportsJun 27

BACH1 inhibits senescence, obesity, and short lifespan by ferroptotic FGF21 secretion

Experiments in mouse cellsFerroptosis

Tissue & CellMay 11

Allicin regulates Sestrin2 ubiquitination to affect macrophage autophagy and senescence, thus inhibiting the growth of hepatoma cells

Experiments in miceInterventions

MetabolismJun 3

Increased expression of sodium-glucose cotransporter 2 and O-GlcNAcylation in hepatocytes drives non-alcoholic steatohepatitis

Experiments in miceInterventions

Toxicology and Applied PharmacologySep 12

Inorganic arsenic exposure-induced premature senescence and senescence-associated secretory phenotype (SASP) in human hepatic stellate cells

Experiments in human cellsSenescence-associated secretory phenotype (SASP)

International ImmunopharmacologyJul 11

Canthaxanthin shows anti-liver aging and anti-liver fibrosis effects by down-regulating inflammation and oxidative stress in vivo and in vitro

Experiments in miceLiver fibrosis

bioRxivJan 2

Secretome of senescent hepatoma cells modulate macrophage polarization and neutrophil extracellular traps formation

Preprint: study in peopleMechanisms