Hematopoietic dysfunction

2 papers

Animals1
In silico1

Latest

8 in 12 months

Frontiers in ImmunologySep 17

Platelet factor 4 in cognitive, immune and hematopoietic aging: emerging evidence and translational challenges

ReviewBlood and immune system

LeukemiaAug 7

SLF2 and SMC5 dysfunction drives HSC aging and predisposes to MDS, defining a new inherited bone marrow failure syndrome

Experiments in human cellsBones and joints

Molecular Biology ReportsJul 8

DNMT3A/TET2-mediated epigenetic alteration in Type-1 diabetes dysregulates the haematopoiesis

ReviewEpigenetic regulation of gene expression

Nature AgingJul 1

Therapeutic inhibition of telomeric DNA damage response rescues hematopoietic dysfunction driven by telomere shortening and aging

Experiments in miceBlood and immune system

Experimental HematologyMar 30

Hematopoietic stem cell senescence and opportunities for intervention

ReviewCellular senescence

Scientific ReportsJan 4

Age- and sex-dependent bone marrow adiposity and distinct transcriptional trajectories in endothelial subtypes

Experiments in miceBones and joints

The Journal of Experimental MedicineDec 31

Molecular and phenotypic blueprint of human hematopoiesis links proliferation stress to stem cell aging

Study in peopleBlood and immune system

Stem Cell Research & TherapyDec 29

Senescence of bone marrow mesenchymal stromal cells: a narrative review of mechanisms, functional consequences, and rejuvenation strategies for age-related disorders

ReviewCellular senescence

MedicineFeb 23

Time-series analysis of hematopoietic stem cells

Computational studyBlood and immune system

Food and Chemical ToxicologySep 10

Oxidative stress-affected ACSL1 hydroxymethylation triggered benzene hematopoietic toxicity by inflammation and senescence

Experiments in animalsMechanisms