Hematological malignancy
Disease2 papers2 findings
- Humans1
Associations
2Clonal hematopoiesis of indeterminate potential
upin humans1
1 study
Clonal hematopoiesis of indeterminate potential
upin humans1
Clonal hematopoiesis of indeterminate potential raises the risk of hematological malignancy in humans.
Review
Clonal hematopoiesis in immune-related and neurological disorders · Immunological medicine · 26 Aug 2026
TET2
upin humans1
1 study
TET2
upin humans1
TET2 raises the risk of hematological malignancy in humans.
Reviewin age-related clonal hematopoiesis of indeterminate potential
TET2 as a Context-Dependent Epigenetic Integrator in Clonal Hematopoiesis, Inflammation, Cancer, and Immunotherapy · Cell biochemistry and function · 1 Aug 2026
Trial sponsors
Company1 trialPhase 1/2351 people
Company1 trialPhase 129 people
Company1 trialPhase 127 people
Nanjing NingQi Medicine Science and Technology
Company1 trialPhase 120 people
2 trialsPhase 2230 people
2 trialsPhase 277 people
1 trialPhase 2126 people
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
1 trialPhase 278 people
Funding
National Cancer InstituteUS$551.2k2 grants since 2024
Latest
21TET deficiency drives selection of aneuploid cells in mice
In mice and mouse cells, disrupting TET enzymes allowed rare pre-existing aneuploid subclones, including chromosome 17 trisomy, to dominate during…In mice and mouse cells, disrupting TET enzymes allowed rare pre-existing aneuploid subclones, including chromosome 17 trisomy, to dominate during rapid cellular expansion.
ASXL1 clonal hematopoiesis is linked to lung cancer risk
In population cohorts, high variant allele fraction ASXL1 mutations were associated with an increased lung cancer hazard ratio of 3.2 among…In population cohorts, high variant allele fraction ASXL1 mutations were associated with an increased lung cancer hazard ratio of 3.2 among ever-smokers.
Raising H3K9 methylation curbs leukemogenesis in mice
Increasing histone 3 lysine 9 methylation reduced leukemogenesis in both young and aged murine cells.Increasing histone 3 lysine 9 methylation reduced leukemogenesis in both young and aged murine cells.