CKM stage
Disease1 paper2 findings
- Humans1
Associations
2JAK2 CHIP
upin humans1
1 study
JAK2 CHIP
upin humans1
JAK2 CHIP is associated with CKM stage in humans (aOR 1.68, 95% CI 1.20-2.35).
Humansmultivariable-adjustedn = 451,460
Clonal haematopoiesis and cardiovascular-kidney-metabolic syndrome: a cohort study · European heart journal · 30 Aug 2026
TET2 CHIP
upin humans1
1 study
TET2 CHIP
upin humans1
TET2 CHIP is associated with CKM stage in humans (aOR 1.10, 95% CI 1.00-1.20).
Humansmultivariable-adjustedn = 451,460
Clonal haematopoiesis and cardiovascular-kidney-metabolic syndrome: a cohort study · European heart journal · 30 Aug 2026
Latest
70Dietary flavonoids link to lower mortality across CKM stages
Top-quartile flavonoid intake lowered odds of stage 2 CKM syndrome to an odds ratio of 0.53 versus stage 0 among 10,754 US adults.Top-quartile flavonoid intake lowered odds of stage 2 CKM syndrome to an odds ratio of 0.53 versus stage 0 among 10,754 US adults.
Advanced CKM syndrome is linked to suicidal death
In 4.6 million Korean adults, advanced CKM stages 3 and 4 were associated with adjusted hazard ratios for suicidal death of 1.328 and 1.319.In 4.6 million Korean adults, advanced CKM stages 3 and 4 were associated with adjusted hazard ratios for suicidal death of 1.328 and 1.319.
Blood proteins improve early cardiometabolic risk prediction
In 43,709 adults with early-stage disease, outcome-specific proteomic signatures improved clinical risk discrimination across 11 incident outcomes…In 43,709 adults with early-stage disease, outcome-specific proteomic signatures improved clinical risk discrimination across 11 incident outcomes, boosting C-index values by 0.024 to 0.070.
Nocturia links to higher mortality in CKM syndrome
Nocturia prevalence rose from 17.6% in stage 0 to 45.97% in stages 3-4 across 11,910 NHANES participants, independently predicting all-cause and…Nocturia prevalence rose from 17.6% in stage 0 to 45.97% in stages 3-4 across 11,910 NHANES participants, independently predicting all-cause and cardiovascular mortality.
Cumulative non-HDL cholesterol is linked to CVD risk
Each 100-unit increase in cumulative exposure was associated with an adjusted hazard ratio of 1.07 for cardiovascular disease over nine years, driven…Each 100-unit increase in cumulative exposure was associated with an adjusted hazard ratio of 1.07 for cardiovascular disease over nine years, driven by earlier stages.