There are 46 papers on heart valve disease in aging research: 4 trials and 29 observational studies in people, 2 in animals, 10 reviews.
4 new papers in 30 daysSee all 57
“five met the primary signal detection criteria: valve disorders (sHR 1.71, 1.20-2.43)”
- Human trial4
- Humans29
- Animals2
- In silico1
Associations
2Atorvastatin
upin humans1
1 study
Atorvastatin
upin humans1
Atorvastatin is linked with a higher risk of heart valve disease in humans (sHR 1.71, 1.20-2.43).
“five met the primary signal detection criteria: valve disorders (sHR 1.71, 1.20-2.43)”
Humansstatin-naïve Medicare beneficiaries aged 65+ after hospitalization for myocardial or cerebral infarction, versus initiating a different new medication6-month follow-up
medRxivPreprint
Alkaline phosphatase
upin dogs1
1 study
Alkaline phosphatase
upin dogs1
Heart valve disease is associated with alkaline phosphatase in dogs (moderate to severe valvular regurgitation).
“Serum alkaline phosphatase levels were significantly higher in the dogs with moderate to severe valvular regurgitation compared to the rest of the cohort.”
Animalsmoderate to severe valvular regurgitationn = 40
GeroScience
Trial sponsors
Company1 trialPhase 3231 people
Company1 trialPhase 2328 people
Company1 trial780 people
Company1 trial53 people
Company1 trial15 people
Company1 trial15 people
Turun Yliopistollinen Keskussairaala
1 trialPhase 4120 people
1 trialPhase 4112 people
Funding
1 grant since 2026National Institute for Health Research£100K