An evolutionary analysis of 2,171 human samples linked common mutations to expansion of normal cells, but found little advantage during progression to cancer.An evolutionary analysis of 2,171 human samples linked common mutations to expansion of normal cells, but found little advantage during progression to cancer.
Computational study of human esophageal tissue samplesMechanisms
Limit: Selection during progression was inferred from sequence data rather than tracked within individual clones
Compared with no surgery, weight-loss surgery was associated with a lower obesity-related cancer rate, with an adjusted rate ratio of 0.81.Compared with no surgery, weight-loss surgery was associated with a lower obesity-related cancer rate, with an adjusted rate ratio of 0.81.
Cohort study of 784,105 adults with recorded obesity, against people with obesity without surgeryObesity
Limit: Obesity severity could confound the association; it was absent from the listed adjustment factors