Early-onset myasthenia gravis

1. Early-onset myasthenia gravis increases HannumAge in silico (OR = 1.100, 95% CI 1.058-1.144, P < 0.001).

   “Reverse MR identified that EOMG causally increased epigenetic clocks (PhenoAge: OR = 1.056, 95% CI 1.004-1.111, P = 0.036; GrimAge: OR = 1.098, 95% CI 1.055-1.143, P < 0.001; HannumAge: OR = 1.100, 95% CI 1.058-1.144, P < 0.001)”

   In silicoreverse Mendelian randomization

   Genetic insights into biological aging and myasthenia gravis: a Mendelian randomization study of telomere length, epigenetic clocks, and mitochondrial DNA copy number

   Clinical epigenetics·14 Feb 2026

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1. HannumAge lowers the risk of early-onset myasthenia gravis in silico (OR = 0.775, 95% CI 0.667-0.901, P = 0.001, PFDR = 0.005).

   “Subgroup analyses showed a negative causal effect of HannumAge on early-onset MG (EOMG) (OR = 0.775, 95% CI 0.667-0.901, P = 0.001, PFDR =0.005)”

   In silicogenetically predicted

   Genetic insights into biological aging and myasthenia gravis: a Mendelian randomization study of telomere length, epigenetic clocks, and mitochondrial DNA copy number

   Clinical epigenetics·14 Feb 2026

More on HannumAge