Cardiac rupture

1. KDM4A has no effect on cardiac rupture in mice.

   “without influencing early cardiac rupture”

   Animalsafter MI

   Inhibiting the Histone Demethylase Kdm4a Restrains Cardiac Fibrosis After Myocardial Infarction by Promoting Autophagy in Premature Senescent Fibroblasts

   Advanced science (Weinheim, Baden-Wurttemberg, Germany)·Apr 15, 2025

More on KDM4A

1. Efferocyte mitochondrial dysfunction induces cardiac rupture.

   “efferocyte mitochondrial dysfunction led to cardiac rupture after myocardial injury.”

   Animalsafter myocardial injuryheart

   Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair

   Cell metabolism·Dec 27, 2018