1 paper
National Heart, Lung, and Blood InstituteUS$3.6mNational Institute on AgingUS$2.8mNational Cancer InstituteUS$1.3m
Sleep pathology and cardiac aging
National Heart, Lung, and Blood InstituteUniv of Massachusetts Med Sch WorcesterUS$99.7k2024–2027
Mechanisms underlying reversal of cardiac aging by urolithin a treatment
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Epicardial remodeling in cardiomyopathy and cardiac aging
National Heart, Lung, and Blood InstituteMayo Clinic RochesterUS$643.4k2011–2029
Neddylation and mitophagy in cardiac aging
National Heart, Lung, and Blood InstituteOhio State UniversityUS$599k2022–2027
Mitochondrial NAD+ Metabolism in Cardiac Aging
National Institute on AgingOklahoma Medical Research FoundationUS$587.1k2024–2029
Autophagy and Megamitochondria in Cardiac Aging and Heart Failure
National Heart, Lung, and Blood InstituteUniversity of California, San DiegoUS$473k2021–2026
Autonomous and Non-Autonomous Regulation of Cardiac Aging
National Institute on AgingIowa State UniversityUS$300.9k2019–2024
An eight-week experiment in 22-month-old mice found comparable benefits in males and females given a ketogenic diet rather than standard chow.An eight-week experiment in 22-month-old mice found comparable benefits in males and females given a ketogenic diet rather than standard chow.
Long-lived African turquoise killifish show ventricular enlargement, fibrosis, and reduced myocardial density with age rather than typical cardiomyocyte hypertrophy.Long-lived African turquoise killifish show ventricular enlargement, fibrosis, and reduced myocardial density with age rather than typical cardiomyocyte hypertrophy.
The compound lowered senescence markers and improved heart function through SIRT3-driven DRP1 deacetylation in aged mice and cultured cardiomyocytes.The compound lowered senescence markers and improved heart function through SIRT3-driven DRP1 deacetylation in aged mice and cultured cardiomyocytes.
Mice lacking the receptor also showed higher inflammation, elevated DNA damage, and a five-month reduction in median lifespan.Mice lacking the receptor also showed higher inflammation, elevated DNA damage, and a five-month reduction in median lifespan.