Autosomal dominant Alzheimer's disease

1. Autosomal dominant Alzheimer's disease increases NfL in humans.

   Humanscarriers relative to non-carriersplasma6 years before expected symptom onset

   Presymptomatic plasma biomarkers in autosomal dominant Alzheimer's disease: sequence and timing · Journal of neurology, neurosurgery, and psychiatry · 24 Aug 2026

NfL →

1. Autosomal dominant Alzheimer's disease increases glial fibrillary acidic protein in humans.

   Humanscarriers relative to non-carriersplasma14 years before expected symptom onset

   Presymptomatic plasma biomarkers in autosomal dominant Alzheimer's disease: sequence and timing · Journal of neurology, neurosurgery, and psychiatry · 24 Aug 2026

Glial fibrillary acidic protein →

1. Autosomal dominant Alzheimer's disease increases phosphorylated tau in humans.

   Humanscarriers diverged from non-carriersplasmaapproximately 21-24 years before expected symptom onset

   Presymptomatic plasma biomarkers in autosomal dominant Alzheimer's disease: sequence and timing · Journal of neurology, neurosurgery, and psychiatry · 24 Aug 2026

Phosphorylated tau →

1. Autosomal dominant Alzheimer's disease increases amyloid-beta 42 in humans.

   Humansmutation carriers relative to non-carriersplasmaapproximately 26 years before expected symptom onset

   Presymptomatic plasma biomarkers in autosomal dominant Alzheimer's disease: sequence and timing · Journal of neurology, neurosurgery, and psychiatry · 24 Aug 2026

Amyloid-beta 42 →