What does the research say about CNIH4?

CNIH4

There are 2 papers on CNIH4 in aging research: 2 observational studies in people. The newest story, Nov 9, 2026: “DNA variants linked to inherited Alzheimer’s disease risk”.

Gene

2 papers study it1 finding

HGNC NCBI Gene Taxon

See all 2 papers on CNIH4

At a glance

The findings reach people, from one lab or study. 1 lab in 1 country.

“The CNIH4 locus association was driven by a missense variant (is caused by Gly54Ser, p<0·0001, odds ratio [OR] 11·99 [5·39-26·64]).”

Identification of genetic modifiers of autosomal dominant Alzheimer's disease: a genome-wide association studyThe Lancet. Neurology2026doi:10.1016/s1474-4422(26)00123-7

1 lab in 1 country

Funders: Alzheimer's Association and others
1 of 1 finding with company ties

Humans2

Associations

Autosomal dominant Alzheimer's disease

upin humans1OR 11.99

1 study

CNIH4 is linked with a higher risk of autosomal dominant Alzheimer's disease in humans (ADAD mutations) (OR 11.99 (5.39-26.64), p<0.0001).
“The CNIH4 locus association was driven by a missense variant (is caused by Gly54Ser, p<0·0001, odds ratio [OR] 11·99 [5·39-26·64]).”
HumansADAD mutations
DNA variants linked to inherited Alzheimer’s disease risk
The Lancet. NeurologyMay 14, 2026

More on Autosomal dominant Alzheimer's disease

Latest

1 paper in 12 months

The Lancet NeurologyMay 14

DNA variants linked to inherited Alzheimer’s disease risk

One DNA variant was associated with higher disease odds, with an odds ratio of 11.99, when 101 symptomatic mutation carriers were compared with 5,050 unaffected controls.One DNA variant was associated with higher disease odds, with an odds ratio of 11.99, when 101 symptomatic mutation carriers were compared with 5,050 unaffected controls.

Genetic association · 5,151 peopleMechanisms