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Atherosclerotic cardiovascular disease susceptibility

Disease

1 paper1 finding

  • Humans1

Associations

1

Shared genetic signals

mixedin silico1

1 study

  1. shared genetic signals are associated with atherosclerotic cardiovascular disease susceptibility in silico (289 linkage disequilibrium-independent lead single-nucleotide polymorphisms mapping to 177 genomic risk loci).

    “identified shared genetic signals associated with ASCVD susceptibility and prioritized candidate protein targets”

    In silicomultivariable ASCVD common factor

    Genetic analysis links shared DNA signals to artery disease

    Journal of the American Heart Association16 Oct 2026

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Journal of the American Heart Association

Genetic analysis links shared DNA signals to artery disease

An observational analysis of human genetic study results identified 289 lead DNA variants across 177 risk regions and prioritised candidate protein targets.An observational analysis of human genetic study results identified 289 lead DNA variants across 177 risk regions and prioritised candidate protein targets.

Genetic association study of participants in human artery disease genetic studiesMechanisms

Limit: The genetic signals concern a modelled ASCVD common factor rather than directly measured disease

Paper

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