Atrial fibrillation/flutter

1. GLP-1 receptor agonists lower the risk of atrial fibrillation/flutter in humans (HR 0.59, 95% CI 0.51–0.69).

   “atrial fibrillation/flutter (HR 0.59, 95% CI 0.51–0.69, p < 0.001)”

   HumansHFpEF, type 2 diabetes, and obesity3 years

   Glucagon-Like Peptide-1 Receptor Agonists with Guideline Therapy Lower Mortality and Hospitalizations in HFpEF: A Propensity-Matched U.S. TriNetX Study

   AHA Scientific Sessions 2025 abstract·Nov 3, 2025

2. GLP-1 receptor agonists lower the risk of atrial fibrillation/flutter in humans (RR 0.63 (95% CI: 0.60-0.66)).

   “atrial fibrillation/flutter (RR, 0.63 (95% CI: 0.60-0.66), p<0.01)”

   Humansin obese patients aged ≥18 years1 year

   Association between Glucagon-like peptide-1 receptor agonists and risk of Arrhythmias: A Contemporary Real-World Analysis

   AHA Scientific Sessions 2025 abstract·Nov 3, 2025

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1. Hypertensive disorders of pregnancy is associated with atrial fibrillation/flutter in humans (HR 1.66; 95% CI 1.31–2.11).

   “HDP was also associated with increased risks of atrial fibrillation/flutter (HR 1.66; 95% CI 1.31–2.11; p<0.001; I2 = 84%)”

   Reviewhistory of hypertensive disorders of pregnancy versus no historyfemales

   Hypertensive disorders of pregnancy and long-term risk of incident cardiac arrhythmias: a meta-analysis

   ESC Congress 2026 abstract·Oct 26, 2026

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1. Semaglutide is associated with atrial fibrillation/flutter in humans (HR 0.42, 95% CI 0.28–0.62).

   “Atrial Fibrillation/Flutter: HR=0.42 (95%CI: 0.28-0.62, p<0.001)”

   HumansNon-Hodgkin lymphoma receiving anthracycline-based regimensn = 994

   Semaglutide tied to survival in non-Hodgkin lymphoma on anthracyclines

   ESC Congress 2026 abstract·Oct 26, 2026

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1. Tobacco use raises the risk of atrial fibrillation/flutter in humans (around 396000 cases, >10000 deaths, 400000 DALYs in 2021).

   “In 2021, AF/AFL related to tobacco caused around 396000 cases, more than 10000 deaths, and 400000 disability-adjusted life years (DALYs).”

   Humans

   Global burden of tobacco-induced atrial fibrillation/flutter: Trends from 1990 to 2021 and projections to 2045 based on the Global Burden of Disease study

   Tobacco induced diseases·Feb 20, 2026

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1. Older age raises the risk of atrial fibrillation/flutter in humans.

   “older age, present period and past cohort were risk factors for the incidence and mortality rate of AF/AFL”

   Humans

   Secular trend in disease burden of atrial fibrillation/flutter in China from 1992 to 2021 and its projection in 25 years

   BMC public health·Jun 3, 2025

1. time raises the risk of atrial fibrillation/flutter in humans (increased annually by 0.46% (95% CI: 0.39-0.52)).

   “the age-standardized incidence rate of AF/AFL in China increased annually by 0.46% (95% CI: 0.39-0.52) in males”

   Humans1992-2021males

   Secular trend in disease burden of atrial fibrillation/flutter in China from 1992 to 2021 and its projection in 25 years

   BMC public health·Jun 3, 2025

1. Frailty raises the risk of atrial fibrillation/flutter in humans (HR = 2.09, 95% CI:(1.41, 3.09), p < 0.001).

   “frailty remained associated with the increased risk of new-onset AF compared with the no frailty group [hazard ratio [HR] = 2.09, 95% CI:(1.41, 3.09), p < 0.001].”

   Humanshypertension3.54 yearsn = 7,316

   Association Between the Frailty and New-Onset Atrial Fibrillation/Flutter Among Elderly Hypertensive Patients

   Frontiers in cardiovascular medicine·May 6, 2022