Molecular Medicine·Feb 22FTO inhibition mitigates high-fat diet-induced metabolic disturbances and cognitive decline in SAMP8 miceExperiments in miceLipid and ceramide metabolismPaper
Biology of Sex Differences·Jan 21Sex differences in cognition, anxiety-phenotype and therapeutic effect of metformin in the aged apoE-TR miceExperiments in miceMetforminPaper
Neuropharmacology·Dec 12Metformin activates the PI3K/AKT/BDNF axis to attenuate postoperative cognitive dysfunctionExperiments in miceMetforminPaper
Journal of Alzheimer's Disease·Dec 6Loss of the mitochondrial protein mitoNEET in mice is associated with cognitive impairments and increased neuroinflammationExperiments in animalsMechanismsPaper
Frontiers in Aging Neuroscience·Dec 4The novel estrogen receptor beta agonist EGX358 and APOE genotype influence memory, vasomotor, and anxiety outcomes in an Alzheimer's mouse modelExperiments in miceAnxietyPaper
Brain, Behavior, and Immunity·Nov 24Ezrin-mediated astrocyte-synapse signaling regulates cognitive function via astrocyte morphological changes in fine processes in male miceExperiments in miceSynaptic transmissionPaper
Experimental Neurology·Nov 23Enhancing cognitive function after traumatic brain injury in male mice: The benefits of running regardless of intervention timingExperiments in miceRunningPaper
GeroScience·Nov 13ACSL3 is a promising therapeutic target for alleviating anxiety and depression in Alzheimer's diseaseExperiments in miceAnxietyPaper
Frontiers in Psychology·Oct 29Exploring the link between sedentary behavior and cognitive decline: a comprehensive study combining Mendelian randomization and animal model experimentsStudy in peopleInterventionsPaper
Physiological Reports·Oct 24The protective effect of angiotensin II type I receptor blocker (valsartan) on behavioral impairment, NLRP3, BDNF, and oxidative stress in the brain tissue of ovariectomized female ratsExperiments in 32 ratsValsartanPaper
Aging Cell·Oct 16Hippocampal Nogo66-NgR1 signaling activation restricts postsynaptic assembly in aged mice with postoperative neurocognitive disordersExperiments in miceSynaptic transmissionPaper
International Journal of Molecular Sciences·Oct 16The Potential Related Genes and Mechanisms Involved in Improving the Treadmill Exercise Ability of APP/PS1 MiceExperiments in miceExercisePaper
Biological Psychiatry·Oct 1Sex-Specific Effects of Anxiety on Cognition and Activity-Dependent Neural Networks: Insights From (Female) Mice and (Wo)menExperiments in miceMechanismsPaper
Brain Research Bulletin·Sep 1Inhibition of the P38 MAPK/NLRP3 pathway mitigates cognitive dysfunction and mood alterations in aged mice after abdominal surgery plus sevofluraneExperiments in micep38 MAPK signalingPaper
ACS Chemical Neuroscience·Aug 31Insights into Vincristine-Induced Peripheral Neuropathy in Aged Rats: Wallerian Degeneration, Oxidative Damage, and Alterations in ATPase EnzymesExperiments in ratsMechanismsPaper
Brain, Behavior, and Immunity·Aug 12BV2-derived extracellular vesicles modulate microglia inflammatory profile, neuronal plasticity, and behavioural performances in late adult miceExperiments in miceInterventionsPaper
Physiological Research·Jul 16The Effect of Omega-3 Fatty Acid Supplementation and Exercise on Locomotor Activity, Exploratory Activity, and Anxiety-Like Behavior in Adult and Aged RatsExperiments in ratsOmega-3 fatty acidsPaper
Heliyon·Jun 13The effect of late-life environmental enrichment on stress and anxiety: The role of sex and age-related differences in coping with aversive stimuliExperiments in animalsAnxietyPaper
Experimental Neurology·Apr 6Voluntary wheel exercise improves glymphatic clearance and ameliorates colitis-associated cognitive impairment in aged mice by inhibiting TRPV4-induced astrocytic calcium activityExperiments in miceCognitive impairmentPaper
Heliyon·Feb 26Whole body vibration ameliorates anxiety-like behavior and memory functions in 30 months old senescent male ratsExperiments in ratsInterventionsPaper
Brain, Behavior, and Immunity·Feb 24Impact of high-fat diet on cognitive behavior and central and systemic inflammation with aging and sex differences in miceExperiments in miceInflammationPaper
Foods·Jan 17Dietary Marine Hydrolysate Improves Memory Performance and Social Behavior through Gut Microbiota Remodeling during AgingExperiments in miceInterventionsPaper
Iranian Journal of Basic Medical Sciences·Jan 2Chronic stress-induced anxiety-like behavior, hippocampal oxidative, and endoplasmic reticulum stress are reversed by young plasma transfusion in aged adult ratsExperiments in ratsAnxietyPaper
Behavioural Brain Research·Dec 24Empagliflozin alleviates diabetes-induced cognitive impairments by lowering nicotinamide adenine dinucleotide phosphate oxidase-4 expression and potentiating the antioxidant defense system in brain tissue of diabetic ratsExperiments in 8 ratsEmpagliflozinPaper
Behavioural Brain Research·Dec 18Intranasal insulin intake and exercise improve memory function in amyloid-β induced Alzheimer's-like disease in rats: Involvement of hippocampal BDNF-TrkB receptorExperiments in ratsTreadmill exercisePaper
Physiology & Behavior·Dec 14Cognitive trajectories in longitudinally trained 3xTg-AD miceExperiments in 20 miceInterventionsPaper
Frontiers in Behavioral Neuroscience·Dec 14Crosstalk between short- and long-term calorie restriction transcriptomic signatures with anxiety-like behavior, aging, and neurodegeneration: implications for drug repurposingExperiments in ratsDietary restrictionPaper
Frontiers in Neuroscience·Dec 11Chronic interleukin-6 mediated neuroinflammation decreases anxiety, and impaires spatial memory in aged female miceExperiments in miceInflammationPaper
Behavioural Brain Research·Nov 10High-intensity interval training ameliorates spatial and recognition memory impairments, reduces hippocampal TNF-alpha levels, and amyloid-beta peptide load in male hypothyroid ratsExperiments in ratsHigh-intensity interval trainingPaper
Life Sciences·Oct 7D-Pinitol attenuates postmenopausal symptoms in ovariectomized miceExperiments in miceInterventionsPaper