4 papers8 findings
Intellectual disability
upin humans1
Intellectual disability is associated with Alzheimer's disease and related dementia in humans (17.6% (184,206/1,046,621)).
“184,206 (17.6%) had claims for ADRD, corresponding to an 11-year prevalence of one case per 5.7 people.”
Humansintellectual disability (excluding Down syndrome)2011 to 2022
American journal on intellectual and developmental disabilities20 Aug 2026
Anxiety
upin humans1OR 2.69
Alzheimer's disease and related dementia raises the risk of anxiety in humans (OR 2.69, 95% CI 1.76-4.11).
“ADRD was associated with increased risks of depression (OR, 95% CI: 2.05, 1.41-2.97) and anxiety (2.69, 1.76-4.11).”
Humans
Physical Activity’s Role in Reducing Neuropsychiatric Symptoms Among Older Adults with Dementia
GSA 2025 abstract31 Dec 2025
Depression
upin humans1OR 2.05
Alzheimer's disease and related dementia raises the risk of depression in humans (OR 2.05, 95% CI 1.41-2.97).
“ADRD was associated with increased risks of depression (OR, 95% CI: 2.05, 1.41-2.97)”
Humans
Physical Activity’s Role in Reducing Neuropsychiatric Symptoms Among Older Adults with Dementia
GSA 2025 abstract31 Dec 2025
Prochlorperazine
downin humans1
Prochlorperazine lowers the risk of Alzheimer's disease and related dementia in humans (IRR 0.8; 95% CI 0.7–0.8).
“prochlorperazine (IRR 0.8; 95%CI 0.7‐0.8).”
Humans
AAIC 2025 abstract23 Dec 2025
Amitriptyline
downin humans1
Amitriptyline lowers the risk of Alzheimer's disease and related dementia in humans (IRR 0.8; 95% CI 0.8–0.9).
“Some protective phenothiazines in our dataset included amitriptyline (IRR 0.8; 95%CI 0.8‐0.9)”
Humans
AAIC 2025 abstract23 Dec 2025
Phenothiazines
downin humans1
Phenothiazines lower the risk of Alzheimer's disease and related dementia in humans (IRR 0.9; 95% CI 0.9–0.97).
“multivariable analysis revealed a significantly lower ADRD prevalence in phenothiazines exposed (≥1phenothiazine) vs unexposed beneficiaries (Incident Rate Ratio 0.9; 95%CI 0.9‐0.97).”
Humansadjusted for demographics and ADRD risk factors
AAIC 2025 abstract23 Dec 2025
Systemic and brain proteomic aging acceleration
upin humans1
Systemic and brain proteomic aging acceleration is associated with Alzheimer's disease and related dementia in humans.
“Systemic and brain proteomic aging acceleration were linked to higher risks of incident MDD and a greater risk of Alzheimer's disease, related dementia, and mortality”
HumansIndividuals with major depressive disorder in UK Biobank
Biological aging acceleration in major depressive disorder: a multi-omics, multi-modal analyses
Research square28 May 2025Preprint
Rural residence
upin humans1
rural residence raises the risk of Alzheimer's disease and related dementia in humans.
“we observed higher dementia prevalence in rural areas based on cognitive tests in the HRS”
Humansbased on cognitive tests in the HRS
ADDRESSING DISPARITIES IN ADRD PREVALENCE AND MORTALITY RATES BETWEEN RURAL AND URBAN COMMUNITIES
GSA 2024 abstract31 Dec 2024
National Institute on AgingUS$20.1mNational Institute of Neurological Disorders and StrokeUS$2.5m
National Institute on AgingUniversity of WashingtonUS$243.9k2024–2028
National Institute of Neurological Disorders and StrokeDuke UniversityUS$1.2m2023–2029
National Institute on AgingUniversity of WashingtonUS$132.4k2024–2025
National Institute on AgingNorthwestern UniversityUS$755k2021–2027
National Institute on AgingUniversity of Miami School of MedicineUS$230k2024–2027
National Institute on AgingOhio State UniversityUS$541k2022–2027
National Institute on AgingWake Forest University Health SciencesUS$770.6k2025–2030
National Institute on AgingUniversity of Southern CaliforniaUS$595.1k2023–2028
National Institute on AgingUniversity of California, BerkeleyUS$722.5k2022–2027
National Institute on AgingUniversity of Texas Hlth Sci Ctr HoustonUS$595.4k2021–2027
Each 1 gram per cubic metre increase in wildfire smoke particles was associated with 1.029 times the rate of Alzheimer’s disease and related dementias.Each 1 gram per cubic metre increase in wildfire smoke particles was associated with 1.029 times the rate of Alzheimer’s disease and related dementias.
An observational analysis of 29,809 White and 7,612 Black adult observations in 2006–2016 linked thinking more strongly to scores counting unusually high and low…An observational analysis of 29,809 White and 7,612 Black adult observations in 2006–2016 linked thinking more strongly to scores counting unusually high and low biological readings.
At 36 months before diagnosis, count-based models reached an AUROC of 0.738 compared with 0.719 for pretrained foundation models in All of Us records.At 36 months before diagnosis, count-based models reached an AUROC of 0.738 compared with 0.719 for pretrained foundation models in All of Us records.
In 563 older adults in Uganda, a brief tablet-based composite score discriminated objective cognitive impairment with a c-statistic of 0.77.In 563 older adults in Uganda, a brief tablet-based composite score discriminated objective cognitive impairment with a c-statistic of 0.77.