4 papers1 finding
Coffee
downin humans1HR 0.3
Coffee is associated with alpha-synucleinopathy in humans (Adjusted HR 0.30, 95% CI 0.11–0.78).
“higher coffee consumption was linked to a lower risk of progression to α-synucleinopathy (aHR [95% CI]: 0.30 [0.11-0.78], P = 0.01).”
HumansIsolated REM sleep behavior disorderHigher consumptionMedian follow-up of 4.2 yearsn = 287
Diet linked to gut microbes and disease progression in sleep disorder
Movement disorders : official journal of the Movement Disorder Society16 Oct 2026
National Institute on AgingUS$1.3mHealth and Medical Research FundHK$1.5mCanadian Institutes of Health Research (CIHR) Project GrantCA$17.5k
National Institute on AgingJohns Hopkins UniversityUS$441.9k2021–2027
Slowing cognitive decline in alpha-synucleinopathies by enhancing physical activity
Canadian Institutes of Health Research (CIHR) Project GrantUniversity of TorontoCA$17.5k2021–2022
Health and Medical Research FundChinese University of Hong KongHK$1.5m2021
An observational study followed 287 people with a sleep disorder for a median 4.2 years and linked dietary patterns to later brain disease.An observational study followed 287 people with a sleep disorder for a median 4.2 years and linked dietary patterns to later brain disease.
In a memory clinic cohort, probable REM sleep behaviour disorder was linked to incident Lewy body dementia with a hazard ratio of 4.82.In a memory clinic cohort, probable REM sleep behaviour disorder was linked to incident Lewy body dementia with a hazard ratio of 4.82.
In PET scans of 77 patients with isolated REM sleep behavior disorder, quantitative dopamine markers showed intermediate loss and predicted phenoconversion toward…In PET scans of 77 patients with isolated REM sleep behavior disorder, quantitative dopamine markers showed intermediate loss and predicted phenoconversion toward Parkinson's disease.