1 paper
Washington University School of Medicine
1 trialPhase 4144 people
1 trialPhase 359 people
Across two cohorts, about 50% of male patients with pancreatic ductal adenocarcinoma had lost the Y chromosome, an alteration enriched in advanced disease.Across two cohorts, about 50% of male patients with pancreatic ductal adenocarcinoma had lost the Y chromosome, an alteration enriched in advanced disease.
In mice and mouse cells, disrupting TET enzymes allowed rare pre-existing aneuploid subclones, including chromosome 17 trisomy, to dominate during rapid cellular…In mice and mouse cells, disrupting TET enzymes allowed rare pre-existing aneuploid subclones, including chromosome 17 trisomy, to dominate during rapid cellular expansion.
Young adult fruit flies housed alone showed faster retrovirus activation, accelerated spread of glial TDP-43 to neurons, and shortened lifespan compared to group-housed…Young adult fruit flies housed alone showed faster retrovirus activation, accelerated spread of glial TDP-43 to neurons, and shortened lifespan compared to group-housed flies.