Younger protein signature

Centenarians are associated with younger protein signature in humans (37 proteins).

“Applying fractional polynomial regressions, we uncovered proteins with linear and non-linear profiles associated with age and identified a subgroup of 37 proteins with a younger signature in centenarians.”

Humansplasma

Plasma Proteome Profiling of Centenarian Across Switzerland Reveals Key Youth-Associated Proteins

Aging cell·1 Feb 2026