White matter hyperintensity progression

Biomarker1 paper1 finding

Humans1

Associations

1

Cognitive decline

upin humans1

1 study

Cognitive decline is associated with white matter hyperintensity progression in humans.
Humansbrainten yearsn = 289
Contribution of cerebrovascular lesions to neurodegeneration and cognitive decline · medRxiv · 6 Oct 2026 · Preprint

Funding

National Institute of Neurological Disorders and StrokeUS$727.9k1 grant since 2022

Vascular Contributors to Blood Brain Barrier Permeability and Regional White Matter Hyperintensity Progression in Young Asymptomatic People
National Institute of Neurological Disorders and StrokeJohns Hopkins UniversityUS$727.9k2022–2027

Latest

3

medRxivHumansPreprintYesterday

Contribution of cerebrovascular lesions to neurodegeneration and cognitive decline

AAIC 2025 AbstractHumans11 Jan

Distinct risk factors drive white matter hyperintensity progression which relates to cognitive performance in individuals at risk of Alzheimer's disease

AAIC 2025 AbstractHumans24 Dec

Glymphatic system function associates with AD‐signature region volumes, plasma biomarkers, and white matter hyperintensity progression in cognitively unimpaired elderly