Higher blood levels of the protein cathepsin B were linked to lower lesion volume, with an association estimate of minus 0.09 in 5,260 people.Higher blood levels of the protein cathepsin B were linked to lower lesion volume, with an association estimate of minus 0.09 in 5,260 people.
Body fat was 1.7 percentage points higher in the quarter eating the most ultraprocessed food than in the quarter eating the least.Body fat was 1.7 percentage points higher in the quarter eating the most ultraprocessed food than in the quarter eating the least.
Cross-sectional study of 8,783 adults without cardiovascular diseasePopulations
Limit: The brain-injury association depended on how ultraprocessed food intake was defined
In experiments, aged mice lacking the protein showed stronger age-linked brain cell activation, but no obvious loss of nerve insulation or faster decline in movement.In experiments, aged mice lacking the protein showed stronger age-linked brain cell activation, but no obvious loss of nerve insulation or faster decline in movement.
Experiments in adult and aged mice, against aged control miceMechanisms
Limit: Whether activation is adaptive or an early, compensated stage of chronic activation remains unknown
Researchers identified three vessel states across disease severity by analysing 11,409 vessel fragments from post-mortem brain tissue from 20 cases.Researchers identified three vessel states across disease severity by analysing 11,409 vessel fragments from post-mortem brain tissue from 20 cases.
Cross-sectional study of 20 brain donors across cerebral small vessel disease severitiesMechanisms
Limit: Controls were not age-matched, so ageing could explain disease-associated vascular differences