White matter

Biomarker

1 paper

  • Humans1

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Stroke

Blood protein linked to lower brain lesion volume

Higher blood levels of the protein cathepsin B were linked to lower lesion volume, with an association estimate of minus 0.09 in 5,260 people.Higher blood levels of the protein cathepsin B were linked to lower lesion volume, with an association estimate of minus 0.09 in 5,260 people.

Study in peopleMechanisms
JAMA Network Open

Higher ultraprocessed food intake linked to brain injury

Body fat was 1.7 percentage points higher in the quarter eating the most ultraprocessed food than in the quarter eating the least.Body fat was 1.7 percentage points higher in the quarter eating the most ultraprocessed food than in the quarter eating the least.

Cross-sectional study of 8,783 adults without cardiovascular diseasePopulations

Limit: The brain-injury association depended on how ultraprocessed food intake was defined

Journal of Neuroinflammation

Protein loss promotes age-linked brain cell activation in mice

In experiments, aged mice lacking the protein showed stronger age-linked brain cell activation, but no obvious loss of nerve insulation or faster decline in movement.In experiments, aged mice lacking the protein showed stronger age-linked brain cell activation, but no obvious loss of nerve insulation or faster decline in movement.

Experiments in adult and aged mice, against aged control miceMechanisms

Limit: Whether activation is adaptive or an early, compensated stage of chronic activation remains unknown

Acta Neuropathologica

Human brain vessels show distinct states in small vessel disease

Researchers identified three vessel states across disease severity by analysing 11,409 vessel fragments from post-mortem brain tissue from 20 cases.Researchers identified three vessel states across disease severity by analysing 11,409 vessel fragments from post-mortem brain tissue from 20 cases.

Cross-sectional study of 20 brain donors across cerebral small vessel disease severitiesMechanisms

Limit: Controls were not age-matched, so ageing could explain disease-associated vascular differences